Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.

Epidemics of communicable diseases place a huge burden on public health infrastructures across the world. Producing accurate and actionable forecasts of infectious disease incidence at short and long time scales will improve public health response to outbreaks. However, scientists and public health...

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Main Authors: Reich, NG, Lauer, SA, Sakrejda, K, Iamsirithaworn, S, Hinjoy, S, Suangtho, P, Suthachana, S, Clapham, HE, Salje, H, Cummings, DA, Lessler, J
Other Authors: Scarpino, SV
Format: Journal article
Language:English
Published: Public Library of Science 2016
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author Reich, NG
Lauer, SA
Sakrejda, K
Iamsirithaworn, S
Hinjoy, S
Suangtho, P
Suthachana, S
Clapham, HE
Salje, H
Cummings, DA
Lessler, J
author2 Scarpino, SV
author_facet Scarpino, SV
Reich, NG
Lauer, SA
Sakrejda, K
Iamsirithaworn, S
Hinjoy, S
Suangtho, P
Suthachana, S
Clapham, HE
Salje, H
Cummings, DA
Lessler, J
author_sort Reich, NG
collection OXFORD
description Epidemics of communicable diseases place a huge burden on public health infrastructures across the world. Producing accurate and actionable forecasts of infectious disease incidence at short and long time scales will improve public health response to outbreaks. However, scientists and public health officials face many obstacles in trying to create such real-time forecasts of infectious disease incidence. Dengue is a mosquito-borne virus that annually infects over 400 million people worldwide. We developed a real-time forecasting model for dengue hemorrhagic fever in the 77 provinces of Thailand. We created a practical computational infrastructure that generated multi-step predictions of dengue incidence in Thai provinces every two weeks throughout 2014. These predictions show mixed performance across provinces, out-performing seasonal baseline models in over half of provinces at a 1.5 month horizon. Additionally, to assess the degree to which delays in case reporting make long-range prediction a challenging task, we compared the performance of our real-time predictions with predictions made with fully reported data. This paper provides valuable lessons for the implementation of real-time predictions in the context of public health decision making.
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spelling oxford-uuid:dddf0d44-d3a5-4e61-b51e-cef7a966f3ae2022-03-27T09:28:01ZChallenges in real-time prediction of infectious disease: A case study of dengue in Thailand.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dddf0d44-d3a5-4e61-b51e-cef7a966f3aeEnglishSymplectic Elements at OxfordPublic Library of Science2016Reich, NGLauer, SASakrejda, KIamsirithaworn, SHinjoy, SSuangtho, PSuthachana, SClapham, HESalje, HCummings, DALessler, JScarpino, SVEpidemics of communicable diseases place a huge burden on public health infrastructures across the world. Producing accurate and actionable forecasts of infectious disease incidence at short and long time scales will improve public health response to outbreaks. However, scientists and public health officials face many obstacles in trying to create such real-time forecasts of infectious disease incidence. Dengue is a mosquito-borne virus that annually infects over 400 million people worldwide. We developed a real-time forecasting model for dengue hemorrhagic fever in the 77 provinces of Thailand. We created a practical computational infrastructure that generated multi-step predictions of dengue incidence in Thai provinces every two weeks throughout 2014. These predictions show mixed performance across provinces, out-performing seasonal baseline models in over half of provinces at a 1.5 month horizon. Additionally, to assess the degree to which delays in case reporting make long-range prediction a challenging task, we compared the performance of our real-time predictions with predictions made with fully reported data. This paper provides valuable lessons for the implementation of real-time predictions in the context of public health decision making.
spellingShingle Reich, NG
Lauer, SA
Sakrejda, K
Iamsirithaworn, S
Hinjoy, S
Suangtho, P
Suthachana, S
Clapham, HE
Salje, H
Cummings, DA
Lessler, J
Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title_full Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title_fullStr Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title_full_unstemmed Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title_short Challenges in real-time prediction of infectious disease: A case study of dengue in Thailand.
title_sort challenges in real time prediction of infectious disease a case study of dengue in thailand
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