The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response.
Rapid waning of anti-polysaccharide bactericidal Ab and vaccine effectiveness is observed following infant immunization with the serogroup C meningococcal (MenC) glycoconjugate vaccine. This is despite the demonstrable presence of immunological memory. Persistence of functional Ab, therefore, appear...
Main Authors: | Blanchard Rohner, G, Snape, MD, Kelly, D, John, T, Morant, A, Yu, L, Borkowski, A, Ceddia, F, Borrow, R, Siegrist, C, Pollard, A |
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Format: | Journal article |
Language: | English |
Published: |
2008
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