Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo
During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018–2020), two experimental EVD vaccines were deployed in North Kivu. This province has been at the centre of conflict in the region for the last 25 years. Amidst ambivalence towards protracted...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
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| _version_ | 1826310351747022848 |
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| author | James, M Kasereka, JG Kasiwa, B Kavunga-Membo, H Kambale, K Grais, R Muyembe-Tamfum, J-J Bausch, DG Watson-Jones, D Lees, S |
| author_facet | James, M Kasereka, JG Kasiwa, B Kavunga-Membo, H Kambale, K Grais, R Muyembe-Tamfum, J-J Bausch, DG Watson-Jones, D Lees, S |
| author_sort | James, M |
| collection | OXFORD |
| description | During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018–2020), two experimental EVD vaccines were deployed in North Kivu. This province has been at the centre of conflict in the region for the last 25 years. Amidst ambivalence towards protracted foreign intervention and controversy about introducing two experimental vaccines, the existing literature has focused on mistrust and ‘resistance’ towards the Ebola response and vaccines. In this article, we examine why people in the eastern DRC did decide to volunteer for a trial of a second EVD vaccine in North Kivu, despite the controversy. Drawing on ethnographic observation, interviews, and focus groups with trial participants conducted between September 2020 and April 2021, we analyse three motivations for participating: protection, health seeking, and expectations surrounding travel requirements. We make three points. First, participation in vaccine trials may be understood locally to have advantages which have not been considered by the trial, because they go beyond medical considerations and are specific to a particular social setting. Second, despite much of the literature focusing on a causal relationship between rumours and ‘vaccine hesitancy’, some rumours may in fact encourage participation. Third, material objects associated with trial participation - such as participant vaccine cards - can hold social and political meaning beyond the confines of the vaccine clinic, and influence decisions surrounding participation. Empirical investigation of how medical interventions become entangled in political economies is essential to understanding the perceived functions of participation, and thus the reasons why people volunteer in clinical trials. Participants' narratives about their decision-making provide an insight into how international bioethical debates interact with, but may also stand apart from, the situated social and economic realities driving decision-making around clinical trials on the ground. This highlights the need for ethical approaches that foreground the political, social, and economic context. |
| first_indexed | 2024-03-07T07:50:40Z |
| format | Journal article |
| id | oxford-uuid:dde9970e-7940-439f-8f40-ed775013e946 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:50:40Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:dde9970e-7940-439f-8f40-ed775013e9462023-07-03T16:23:46ZProtection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the CongoJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dde9970e-7940-439f-8f40-ed775013e946EnglishSymplectic ElementsElsevier2023James, MKasereka, JGKasiwa, BKavunga-Membo, HKambale, KGrais, RMuyembe-Tamfum, J-JBausch, DGWatson-Jones, DLees, SDuring the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018–2020), two experimental EVD vaccines were deployed in North Kivu. This province has been at the centre of conflict in the region for the last 25 years. Amidst ambivalence towards protracted foreign intervention and controversy about introducing two experimental vaccines, the existing literature has focused on mistrust and ‘resistance’ towards the Ebola response and vaccines. In this article, we examine why people in the eastern DRC did decide to volunteer for a trial of a second EVD vaccine in North Kivu, despite the controversy. Drawing on ethnographic observation, interviews, and focus groups with trial participants conducted between September 2020 and April 2021, we analyse three motivations for participating: protection, health seeking, and expectations surrounding travel requirements. We make three points. First, participation in vaccine trials may be understood locally to have advantages which have not been considered by the trial, because they go beyond medical considerations and are specific to a particular social setting. Second, despite much of the literature focusing on a causal relationship between rumours and ‘vaccine hesitancy’, some rumours may in fact encourage participation. Third, material objects associated with trial participation - such as participant vaccine cards - can hold social and political meaning beyond the confines of the vaccine clinic, and influence decisions surrounding participation. Empirical investigation of how medical interventions become entangled in political economies is essential to understanding the perceived functions of participation, and thus the reasons why people volunteer in clinical trials. Participants' narratives about their decision-making provide an insight into how international bioethical debates interact with, but may also stand apart from, the situated social and economic realities driving decision-making around clinical trials on the ground. This highlights the need for ethical approaches that foreground the political, social, and economic context. |
| spellingShingle | James, M Kasereka, JG Kasiwa, B Kavunga-Membo, H Kambale, K Grais, R Muyembe-Tamfum, J-J Bausch, DG Watson-Jones, D Lees, S Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title | Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title_full | Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title_fullStr | Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title_full_unstemmed | Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title_short | Protection, health seeking, or a laissez-passer: participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo |
| title_sort | protection health seeking or a laissez passer participants decision making in an evd vaccine trial in the eastern democratic republic of the congo |
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