Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells.
The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In b...
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1826300504291934208 |
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| author | Müller, I Cobbold, S Waldmann, H Kaufmann, S |
| author_facet | Müller, I Cobbold, S Waldmann, H Kaufmann, S |
| author_sort | Müller, I |
| collection | OXFORD |
| description | The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mice showing more pronounced effects. Simultaneous depletion of L3T4+ and Lyt-2+ T cells did not further exacerbate infection. These findings suggest that both L3T4+ and Lyt-2+ T cells are involved in the acquisition of resistance against tuberculosis. |
| first_indexed | 2024-03-07T05:18:10Z |
| format | Journal article |
| id | oxford-uuid:ddf563a6-f695-4c59-8d42-798101cbd4b1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:18:10Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:ddf563a6-f695-4c59-8d42-798101cbd4b12022-03-27T09:28:39ZImpaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ddf563a6-f695-4c59-8d42-798101cbd4b1EnglishSymplectic Elements at Oxford1987Müller, ICobbold, SWaldmann, HKaufmann, SThe resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mice showing more pronounced effects. Simultaneous depletion of L3T4+ and Lyt-2+ T cells did not further exacerbate infection. These findings suggest that both L3T4+ and Lyt-2+ T cells are involved in the acquisition of resistance against tuberculosis. |
| spellingShingle | Müller, I Cobbold, S Waldmann, H Kaufmann, S Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title | Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title_full | Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title_fullStr | Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title_full_unstemmed | Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title_short | Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. |
| title_sort | impaired resistance to mycobacterium tuberculosis infection after selective in vivo depletion of l3t4 and lyt 2 t cells |
| work_keys_str_mv | AT mulleri impairedresistancetomycobacteriumtuberculosisinfectionafterselectiveinvivodepletionofl3t4andlyt2tcells AT cobbolds impairedresistancetomycobacteriumtuberculosisinfectionafterselectiveinvivodepletionofl3t4andlyt2tcells AT waldmannh impairedresistancetomycobacteriumtuberculosisinfectionafterselectiveinvivodepletionofl3t4andlyt2tcells AT kaufmanns impairedresistancetomycobacteriumtuberculosisinfectionafterselectiveinvivodepletionofl3t4andlyt2tcells |