Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.

Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.

PURPOSE: To evaluate tumor response, pharmacodynamic effects, and safety of a combination of lomeguatrib (LM), an O6-methylguanine DNA-methyltransferase (MGMT) inactivator, and temozolomide (TMZ), TMZ alone, and LM/TMZ after disease progression on TMZ alone in patients with advanced melanoma. PATIE...

Full description

Bibliographic Details
Main Authors: Ranson, M, Hersey, P, Thompson, D, Beith, J, McArthur, G, Haydon, A, Davis, I, Kefford, R, Mortimer, P, Harris, P, Baka, S, Seebaran, A, Sabharwal, A, Watson, A, Margison, G, Middleton, MR
Format: Journal article
Language:English
Published: 2007

Similar Items