Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.
The human tumor suppressor gene PTEN encodes a putative cytoskeleton-associated molecule with both protein phosphatase and phosphatidylinositol 3,4,5-trisphosphate (PIP3) 3-phosphatase activities. In cell culture, the lipid phosphatase activity of this protein is involved in regulating cell prolifer...
Main Authors: | Goberdhan, D, Paricio, N, Goodman, E, Mlodzik, M, Wilson, C |
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Format: | Journal article |
Language: | English |
Published: |
1999
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