Parallel NMR supersequences: ten spectra in a single measurement
The principles employed in parallel NMR and MRI are applied to NMR supersequences yielding as many as ten 2D NMR spectra in one measurement. We present a number of examples where two NOAH (NMR by Ordered Acquisition using 1H-detection) supersequences are recorded in parallel, thus dramatically incre...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2021
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| _version_ | 1826300523233411072 |
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| author | Kupče, Ē Yong, JRJ Widmalm, G Claridge, TDW |
| author_facet | Kupče, Ē Yong, JRJ Widmalm, G Claridge, TDW |
| author_sort | Kupče, Ē |
| collection | OXFORD |
| description | The principles employed in parallel NMR and MRI are applied to NMR supersequences yielding as many as ten 2D NMR spectra in one measurement. We present a number of examples where two NOAH (NMR by Ordered Acquisition using 1H-detection) supersequences are recorded in parallel, thus dramatically increasing the information content obtained in a single NMR experiment. The two parallel supersequences entangled by time-sharing schemes (IPAP-seHSQC, HSQC-COSY, and HSQC-TOCSY) incorporate also modified (sequential and/or interleaved) conventional pulse schemes (modules), including HMBC, TOCSY, COSY, CLIP-COSY, NOESY, and ROESY. Such parallel supersequences can be tailored for specific applications, for instance, the analysis and characterization of molecular structure of complex organic molecules from a single measurement. In particular, the CASPER software was used to establish the structure of a tetrasaccharide, β-LNnTOMe, with a high degree of confidence from a single measurement involving a parallel NOAH-5 supersequence. |
| first_indexed | 2024-03-07T05:18:27Z |
| format | Journal article |
| id | oxford-uuid:de0c60b2-a2c6-4153-a35a-8de386941853 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:18:27Z |
| publishDate | 2021 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:de0c60b2-a2c6-4153-a35a-8de3869418532022-03-27T09:29:30ZParallel NMR supersequences: ten spectra in a single measurementJournal articlehttp://purl.org/coar/resource_type/c_545buuid:de0c60b2-a2c6-4153-a35a-8de386941853EnglishSymplectic ElementsAmerican Chemical Society2021Kupče, ĒYong, JRJWidmalm, GClaridge, TDWThe principles employed in parallel NMR and MRI are applied to NMR supersequences yielding as many as ten 2D NMR spectra in one measurement. We present a number of examples where two NOAH (NMR by Ordered Acquisition using 1H-detection) supersequences are recorded in parallel, thus dramatically increasing the information content obtained in a single NMR experiment. The two parallel supersequences entangled by time-sharing schemes (IPAP-seHSQC, HSQC-COSY, and HSQC-TOCSY) incorporate also modified (sequential and/or interleaved) conventional pulse schemes (modules), including HMBC, TOCSY, COSY, CLIP-COSY, NOESY, and ROESY. Such parallel supersequences can be tailored for specific applications, for instance, the analysis and characterization of molecular structure of complex organic molecules from a single measurement. In particular, the CASPER software was used to establish the structure of a tetrasaccharide, β-LNnTOMe, with a high degree of confidence from a single measurement involving a parallel NOAH-5 supersequence. |
| spellingShingle | Kupče, Ē Yong, JRJ Widmalm, G Claridge, TDW Parallel NMR supersequences: ten spectra in a single measurement |
| title | Parallel NMR supersequences: ten spectra in a single measurement |
| title_full | Parallel NMR supersequences: ten spectra in a single measurement |
| title_fullStr | Parallel NMR supersequences: ten spectra in a single measurement |
| title_full_unstemmed | Parallel NMR supersequences: ten spectra in a single measurement |
| title_short | Parallel NMR supersequences: ten spectra in a single measurement |
| title_sort | parallel nmr supersequences ten spectra in a single measurement |
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