In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.

In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we de...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Speiser, D, Pittet, M, Valmori, D, Dunbar, R, Rimoldi, D, Liénard, D, MacDonald, H, Cerottini, J, Cerundolo, V, Romero, P
Format: Journal article
Język:English
Wydane: 1999
Opis
Streszczenie:Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.

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