In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.
Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we de...
| Hauptverfasser: | , , , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
1999
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| _version_ | 1826300533124628480 |
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| author | Speiser, D Pittet, M Valmori, D Dunbar, R Rimoldi, D Liénard, D MacDonald, H Cerottini, J Cerundolo, V Romero, P |
| author_facet | Speiser, D Pittet, M Valmori, D Dunbar, R Rimoldi, D Liénard, D MacDonald, H Cerottini, J Cerundolo, V Romero, P |
| author_sort | Speiser, D |
| collection | OXFORD |
| description | Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo. |
| first_indexed | 2024-03-07T05:18:36Z |
| format | Journal article |
| id | oxford-uuid:de1a40ab-cdfc-4dc5-8bfa-48992d07ebd0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:18:36Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:de1a40ab-cdfc-4dc5-8bfa-48992d07ebd02022-03-27T09:29:43ZIn vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:de1a40ab-cdfc-4dc5-8bfa-48992d07ebd0EnglishSymplectic Elements at Oxford1999Speiser, DPittet, MValmori, DDunbar, RRimoldi, DLiénard, DMacDonald, HCerottini, JCerundolo, VRomero, PNatural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo. |
| spellingShingle | Speiser, D Pittet, M Valmori, D Dunbar, R Rimoldi, D Liénard, D MacDonald, H Cerottini, J Cerundolo, V Romero, P In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title | In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title_full | In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title_fullStr | In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title_full_unstemmed | In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title_short | In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. |
| title_sort | in vivo expression of natural killer cell inhibitory receptors by human melanoma specific cytolytic t lymphocytes |
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