Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation.
Serotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT receptor ligands has allowed the assessment of specific 5-HT receptor subtype function using neuroendocrine methods. Studies with selecti...
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| Format: | Conference item |
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1993
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| _version_ | 1826300540218245120 |
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| author | Cowen, P |
| author_facet | Cowen, P |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Serotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT receptor ligands has allowed the assessment of specific 5-HT receptor subtype function using neuroendocrine methods. Studies with selective antagonists have shown that the endocrine responses to the 5-HT precursor L-tryptophan (LTP) are mediated via postsynaptic 5-HT1A receptors, whereas endocrine responses produced by the 5-HT-releasing agent d-fenfluramine involve postsynaptic 5-HT2/1C receptors. Endocrine responses to both LTP and fenfluramine are consistently decreased in depressive illness. In contrast, endocrine responses to direct 5-HT1A and 5-HT2/1C receptor agonists are not consistently attenuated in depressed patients. The current data suggest that depressive illness is associated with an impairment of 5-HT neurotransmission that involves decreased 5-HT release rather than altered sensitivity of postsynaptic 5-HT receptors. |
| first_indexed | 2024-03-07T05:18:43Z |
| format | Conference item |
| id | oxford-uuid:de22712b-3ffd-413c-b9db-469ef1c7bd50 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:18:43Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:de22712b-3ffd-413c-b9db-469ef1c7bd502022-03-27T09:29:58ZSerotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:de22712b-3ffd-413c-b9db-469ef1c7bd50Symplectic Elements at Oxford1993Cowen, PSerotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT receptor ligands has allowed the assessment of specific 5-HT receptor subtype function using neuroendocrine methods. Studies with selective antagonists have shown that the endocrine responses to the 5-HT precursor L-tryptophan (LTP) are mediated via postsynaptic 5-HT1A receptors, whereas endocrine responses produced by the 5-HT-releasing agent d-fenfluramine involve postsynaptic 5-HT2/1C receptors. Endocrine responses to both LTP and fenfluramine are consistently decreased in depressive illness. In contrast, endocrine responses to direct 5-HT1A and 5-HT2/1C receptor agonists are not consistently attenuated in depressed patients. The current data suggest that depressive illness is associated with an impairment of 5-HT neurotransmission that involves decreased 5-HT release rather than altered sensitivity of postsynaptic 5-HT receptors. |
| spellingShingle | Cowen, P Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title | Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title_full | Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title_fullStr | Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title_full_unstemmed | Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title_short | Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. |
| title_sort | serotonin receptor subtypes in depression evidence from studies in neuroendocrine regulation |
| work_keys_str_mv | AT cowenp serotoninreceptorsubtypesindepressionevidencefromstudiesinneuroendocrineregulation |