A cortical substrate for the long-term memory of saccadic eye movements calibration
How movements are continuously adapted to physiological and environmental changes is a fundamental question in systems neuroscience. While many studies have elucidated the mechanisms which underlie short-term sensorimotor adaptation (∼10–30 min), how these motor memories are maintained over longer-t...
| Главные авторы: | , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Elsevier
2018
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| _version_ | 1826300559350562816 |
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| author | Pélisson, D Habchi, O Panouillères, M Hernoux, C Farnè, A |
| author_facet | Pélisson, D Habchi, O Panouillères, M Hernoux, C Farnè, A |
| author_sort | Pélisson, D |
| collection | OXFORD |
| description | How movements are continuously adapted to physiological and environmental changes is a fundamental question in systems neuroscience. While many studies have elucidated the mechanisms which underlie short-term sensorimotor adaptation (∼10–30 min), how these motor memories are maintained over longer-term (>3–5 days) -and thanks to which neural systems-is virtually unknown. Here, we examine in healthy human participants whether the temporo-parietal junction (TPJ) is causally involved in the induction and/or the retention of saccadic eye movements' adaptation. Single-pulse transcranial magnetic stimulation (spTMS) was applied while subjects performed a ∼15min size-decrease adaptation task of leftward reactive saccades. A TMS pulse was delivered over the TPJ in the right hemisphere (rTPJ) in each trial either 30, 60, 90 or 120 msec (in 4 separate adaptation sessions) after the saccade onset. In two control groups of subjects, the same adaptation procedure was achieved either alone (No-TMS) or combined with spTMS applied over the vertex (SHAM-TMS). While the timing of spTMS over the rTPJ did not significantly affect the speed and immediate after-effect of adaptation, we found that the amount of adaptation retention measured 10 days later was markedly larger (42%) than in both the No-TMS (21%) and the SHAM-TMS (11%) control groups. These results demonstrate for the first time that the cerebral cortex is causally involved in maintaining long-term oculomotor memories. |
| first_indexed | 2024-03-07T05:19:01Z |
| format | Journal article |
| id | oxford-uuid:de3ae42a-e171-42db-a331-29d4484f5b0a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:19:01Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:de3ae42a-e171-42db-a331-29d4484f5b0a2022-03-27T09:30:46ZA cortical substrate for the long-term memory of saccadic eye movements calibrationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:de3ae42a-e171-42db-a331-29d4484f5b0aEnglishSymplectic Elements at OxfordElsevier2018Pélisson, DHabchi, OPanouillères, MHernoux, CFarnè, AHow movements are continuously adapted to physiological and environmental changes is a fundamental question in systems neuroscience. While many studies have elucidated the mechanisms which underlie short-term sensorimotor adaptation (∼10–30 min), how these motor memories are maintained over longer-term (>3–5 days) -and thanks to which neural systems-is virtually unknown. Here, we examine in healthy human participants whether the temporo-parietal junction (TPJ) is causally involved in the induction and/or the retention of saccadic eye movements' adaptation. Single-pulse transcranial magnetic stimulation (spTMS) was applied while subjects performed a ∼15min size-decrease adaptation task of leftward reactive saccades. A TMS pulse was delivered over the TPJ in the right hemisphere (rTPJ) in each trial either 30, 60, 90 or 120 msec (in 4 separate adaptation sessions) after the saccade onset. In two control groups of subjects, the same adaptation procedure was achieved either alone (No-TMS) or combined with spTMS applied over the vertex (SHAM-TMS). While the timing of spTMS over the rTPJ did not significantly affect the speed and immediate after-effect of adaptation, we found that the amount of adaptation retention measured 10 days later was markedly larger (42%) than in both the No-TMS (21%) and the SHAM-TMS (11%) control groups. These results demonstrate for the first time that the cerebral cortex is causally involved in maintaining long-term oculomotor memories. |
| spellingShingle | Pélisson, D Habchi, O Panouillères, M Hernoux, C Farnè, A A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title | A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title_full | A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title_fullStr | A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title_full_unstemmed | A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title_short | A cortical substrate for the long-term memory of saccadic eye movements calibration |
| title_sort | cortical substrate for the long term memory of saccadic eye movements calibration |
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