Clinical imaging of tumor angiogenesis.
Angiogenesis is an integral part of tumor growth and invasion. This has led to the emergence of several antiangiogenic therapies and stimulated efforts to accurately evaluate the extent of angiogenesis before and in response to anticancer treatment. The most commonly used approach has been the asses...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797099113312944128 |
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| author | Patel, N Harris, A Gleeson, F Vallis, K |
| author_facet | Patel, N Harris, A Gleeson, F Vallis, K |
| author_sort | Patel, N |
| collection | OXFORD |
| description | Angiogenesis is an integral part of tumor growth and invasion. This has led to the emergence of several antiangiogenic therapies and stimulated efforts to accurately evaluate the extent of angiogenesis before and in response to anticancer treatment. The most commonly used approach has been the assessment of new vessel formation in histological samples. However, it is becoming apparent that this is insufficient for a full understanding of tumor physiology and for in vivo guidance of cancer management. Imaging has the potential to provide noninvasive and repeatable assessment of the angiogenic process. Imaging approaches use a variety of modalities and are aimed at either assessment of the functional integrity of tumor vasculature or assessment of its molecular status. This review summarizes the aims and methods of clinical tumor angiogenesis imaging, including present technologies and ones that will be developed within the next 5-10 years. |
| first_indexed | 2024-03-07T05:19:01Z |
| format | Journal article |
| id | oxford-uuid:de3c1c7c-5fd8-4217-9d1c-85cab139e2b8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:19:01Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:de3c1c7c-5fd8-4217-9d1c-85cab139e2b82022-03-27T09:30:53ZClinical imaging of tumor angiogenesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:de3c1c7c-5fd8-4217-9d1c-85cab139e2b8EnglishSymplectic Elements at Oxford2012Patel, NHarris, AGleeson, FVallis, KAngiogenesis is an integral part of tumor growth and invasion. This has led to the emergence of several antiangiogenic therapies and stimulated efforts to accurately evaluate the extent of angiogenesis before and in response to anticancer treatment. The most commonly used approach has been the assessment of new vessel formation in histological samples. However, it is becoming apparent that this is insufficient for a full understanding of tumor physiology and for in vivo guidance of cancer management. Imaging has the potential to provide noninvasive and repeatable assessment of the angiogenic process. Imaging approaches use a variety of modalities and are aimed at either assessment of the functional integrity of tumor vasculature or assessment of its molecular status. This review summarizes the aims and methods of clinical tumor angiogenesis imaging, including present technologies and ones that will be developed within the next 5-10 years. |
| spellingShingle | Patel, N Harris, A Gleeson, F Vallis, K Clinical imaging of tumor angiogenesis. |
| title | Clinical imaging of tumor angiogenesis. |
| title_full | Clinical imaging of tumor angiogenesis. |
| title_fullStr | Clinical imaging of tumor angiogenesis. |
| title_full_unstemmed | Clinical imaging of tumor angiogenesis. |
| title_short | Clinical imaging of tumor angiogenesis. |
| title_sort | clinical imaging of tumor angiogenesis |
| work_keys_str_mv | AT pateln clinicalimagingoftumorangiogenesis AT harrisa clinicalimagingoftumorangiogenesis AT gleesonf clinicalimagingoftumorangiogenesis AT vallisk clinicalimagingoftumorangiogenesis |