Worming out the biology of Runx.
Runx family transcription factors have risen to prominence over the last few years because of the increasing evidence implicating them as key regulators of the choice between cell proliferation and differentiation during development and carcinogenesis. Runx factors have been found to be involved in...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2008
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| _version_ | 1797099173136302080 |
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| author | Nimmo, R Woollard, A |
| author_facet | Nimmo, R Woollard, A |
| author_sort | Nimmo, R |
| collection | OXFORD |
| description | Runx family transcription factors have risen to prominence over the last few years because of the increasing evidence implicating them as key regulators of the choice between cell proliferation and differentiation during development and carcinogenesis. Runx factors have been found to be involved in diverse developmental processes, ranging from hematopoiesis to neurogenesis, and are increasingly being linked with various human cancers. In this review, we examine the case for Runx factors as key regulators of cell proliferation in various developmental situations, a role that predisposes Runx mutations as causative agents in oncogenesis. We discuss the evidence that Runx factors regulate, and are regulated by, core components of the cell cycle machinery, and focus our attention on the solo Runx gene, rnt-1, in Caenorhabditis elegans, an organism that we feel has much to offer the Runx field. |
| first_indexed | 2024-03-07T05:19:55Z |
| format | Journal article |
| id | oxford-uuid:de889b08-ca4f-44e3-b024-e62433f0ec4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:19:55Z |
| publishDate | 2008 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:de889b08-ca4f-44e3-b024-e62433f0ec4a2022-03-27T09:32:53ZWorming out the biology of Runx.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:de889b08-ca4f-44e3-b024-e62433f0ec4aEnglishSymplectic Elements at OxfordElsevier2008Nimmo, RWoollard, ARunx family transcription factors have risen to prominence over the last few years because of the increasing evidence implicating them as key regulators of the choice between cell proliferation and differentiation during development and carcinogenesis. Runx factors have been found to be involved in diverse developmental processes, ranging from hematopoiesis to neurogenesis, and are increasingly being linked with various human cancers. In this review, we examine the case for Runx factors as key regulators of cell proliferation in various developmental situations, a role that predisposes Runx mutations as causative agents in oncogenesis. We discuss the evidence that Runx factors regulate, and are regulated by, core components of the cell cycle machinery, and focus our attention on the solo Runx gene, rnt-1, in Caenorhabditis elegans, an organism that we feel has much to offer the Runx field. |
| spellingShingle | Nimmo, R Woollard, A Worming out the biology of Runx. |
| title | Worming out the biology of Runx. |
| title_full | Worming out the biology of Runx. |
| title_fullStr | Worming out the biology of Runx. |
| title_full_unstemmed | Worming out the biology of Runx. |
| title_short | Worming out the biology of Runx. |
| title_sort | worming out the biology of runx |
| work_keys_str_mv | AT nimmor wormingoutthebiologyofrunx AT woollarda wormingoutthebiologyofrunx |