Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum.
BACKGROUND: Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined. METHODS: All laboratory-confirmed episodes of malaria in Timika, Papua, Indonesia, presenting to community primary care clinics...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
BioMed Central
2008
|
| _version_ | 1826300640127614976 |
|---|---|
| author | Karyana, M Burdarm, L Yeung, S Kenangalem, E Wariker, N Maristela, R Umana, K Vemuri, R Okoseray, M Penttinen, P Ebsworth, P Sugiarto, P Anstey, N Tjitra, E Price, R |
| author_facet | Karyana, M Burdarm, L Yeung, S Kenangalem, E Wariker, N Maristela, R Umana, K Vemuri, R Okoseray, M Penttinen, P Ebsworth, P Sugiarto, P Anstey, N Tjitra, E Price, R |
| author_sort | Karyana, M |
| collection | OXFORD |
| description | BACKGROUND: Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined. METHODS: All laboratory-confirmed episodes of malaria in Timika, Papua, Indonesia, presenting to community primary care clinics and an inpatient facility were reviewed over a two-year period. In addition information was gathered from a house-to-house survey to quantify the prevalence of malaria and treatment-seeking behaviour of people with fever. RESULTS: Between January 2004 and December 2005, 99,158 laboratory-confirmed episodes of malaria were reported, of which 58% (57,938) were attributable to P. falciparum and 37% (36,471) to P. vivax. Malaria was most likely to be attributable to pure P. vivax in children under one year of age (55% 2,684/4,889). In the household survey, the prevalence of asexual parasitaemia was 7.5% (290/3,890) for P. falciparum and 6.4% (248/3,890) for P. vivax. The prevalence of P. falciparum infection peaked in young adults aged 15-25 years (9.8% 69/707), compared to P. vivax infection which peaked in children aged 1 to 4 years (9.5% 61/642). Overall 35% (1,813/5,255) of people questioned reported a febrile episode in the preceding month. Of the 60% of people who were estimated to have had malaria, only 39% would have been detected by the surveillance network. The overall incidence of malaria was therefore estimated as 876 per 1,000 per year (Range: 711-906). CONCLUSION: In this region of multidrug-resistant P. vivax and P. falciparum, both species are associated with substantial morbidity, but with significant differences in the age-related risk of infection. |
| first_indexed | 2024-03-07T05:20:15Z |
| format | Journal article |
| id | oxford-uuid:dea1f1e1-1c15-4b49-9d4e-e8a84b43198a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:20:15Z |
| publishDate | 2008 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:dea1f1e1-1c15-4b49-9d4e-e8a84b43198a2022-03-27T09:33:44ZMalaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dea1f1e1-1c15-4b49-9d4e-e8a84b43198aEnglishSymplectic Elements at OxfordBioMed Central2008Karyana, MBurdarm, LYeung, SKenangalem, EWariker, NMaristela, RUmana, KVemuri, ROkoseray, MPenttinen, PEbsworth, PSugiarto, PAnstey, NTjitra, EPrice, R BACKGROUND: Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined. METHODS: All laboratory-confirmed episodes of malaria in Timika, Papua, Indonesia, presenting to community primary care clinics and an inpatient facility were reviewed over a two-year period. In addition information was gathered from a house-to-house survey to quantify the prevalence of malaria and treatment-seeking behaviour of people with fever. RESULTS: Between January 2004 and December 2005, 99,158 laboratory-confirmed episodes of malaria were reported, of which 58% (57,938) were attributable to P. falciparum and 37% (36,471) to P. vivax. Malaria was most likely to be attributable to pure P. vivax in children under one year of age (55% 2,684/4,889). In the household survey, the prevalence of asexual parasitaemia was 7.5% (290/3,890) for P. falciparum and 6.4% (248/3,890) for P. vivax. The prevalence of P. falciparum infection peaked in young adults aged 15-25 years (9.8% 69/707), compared to P. vivax infection which peaked in children aged 1 to 4 years (9.5% 61/642). Overall 35% (1,813/5,255) of people questioned reported a febrile episode in the preceding month. Of the 60% of people who were estimated to have had malaria, only 39% would have been detected by the surveillance network. The overall incidence of malaria was therefore estimated as 876 per 1,000 per year (Range: 711-906). CONCLUSION: In this region of multidrug-resistant P. vivax and P. falciparum, both species are associated with substantial morbidity, but with significant differences in the age-related risk of infection. |
| spellingShingle | Karyana, M Burdarm, L Yeung, S Kenangalem, E Wariker, N Maristela, R Umana, K Vemuri, R Okoseray, M Penttinen, P Ebsworth, P Sugiarto, P Anstey, N Tjitra, E Price, R Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title | Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title_full | Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title_fullStr | Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title_full_unstemmed | Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title_short | Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. |
| title_sort | malaria morbidity in papua indonesia an area with multidrug resistant plasmodium vivax and plasmodium falciparum |
| work_keys_str_mv | AT karyanam malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT burdarml malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT yeungs malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT kenangaleme malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT warikern malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT maristelar malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT umanak malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT vemurir malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT okoseraym malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT penttinenp malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT ebsworthp malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT sugiartop malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT ansteyn malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT tjitrae malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum AT pricer malariamorbidityinpapuaindonesiaanareawithmultidrugresistantplasmodiumvivaxandplasmodiumfalciparum |