Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction.
Magnetic resonance imaging provides a non-invasive method for investigating functional changes in the human placenta in vivo. In this study, we combine a magnetic resonance imaging technique called magnetization transfer with established stereological methods in order to analyse and compare placenta...
| Үндсэн зохиолчид: | , , , , , , |
|---|---|
| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2004
|
| _version_ | 1826300668308094976 |
|---|---|
| author | Ong, S Tyler, D Moore, R Gowland, P Baker, P Johnson, I Mayhew, T |
| author_facet | Ong, S Tyler, D Moore, R Gowland, P Baker, P Johnson, I Mayhew, T |
| author_sort | Ong, S |
| collection | OXFORD |
| description | Magnetic resonance imaging provides a non-invasive method for investigating functional changes in the human placenta in vivo. In this study, we combine a magnetic resonance imaging technique called magnetization transfer with established stereological methods in order to analyse and compare placentae from normal (16-36 weeks of gestation) and complicated (pre-eclampsia, intrauterine growth restriction) pregnancies. Magnetization transfer provided an in vivo measure of the ratio of bound protons:total protons and stereological analysis of histological sections was used to estimate a residual:total volume ratio (the ratio of non-vascular volume to total placental volume). Statistical comparisons were drawn using tests for related samples (longitudinal data) or one-way analysis of variance (cross-sectional data). We found no significant differences in magnetization transfer between gestational age groups or between uncomplicated pregnancies and pregnancies complicated by pre-eclampsia or intrauterine growth restriction. In comparable groups of different subjects, stereological analyses also failed to demonstrate significant differences in residual:total volume ratios. We conclude that [a] the ratio of non-vascular volume:total placental volume does not alter between 16 and 36 weeks of normal gestation, and [b] this integrated response is also conserved in pre-eclampsia and intrauterine growth restriction. |
| first_indexed | 2024-03-07T05:20:39Z |
| format | Journal article |
| id | oxford-uuid:dec757dd-ba80-43e7-a90c-30bf93f099a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:20:39Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:dec757dd-ba80-43e7-a90c-30bf93f099a62022-03-27T09:34:38ZFunctional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dec757dd-ba80-43e7-a90c-30bf93f099a6EnglishSymplectic Elements at Oxford2004Ong, STyler, DMoore, RGowland, PBaker, PJohnson, IMayhew, TMagnetic resonance imaging provides a non-invasive method for investigating functional changes in the human placenta in vivo. In this study, we combine a magnetic resonance imaging technique called magnetization transfer with established stereological methods in order to analyse and compare placentae from normal (16-36 weeks of gestation) and complicated (pre-eclampsia, intrauterine growth restriction) pregnancies. Magnetization transfer provided an in vivo measure of the ratio of bound protons:total protons and stereological analysis of histological sections was used to estimate a residual:total volume ratio (the ratio of non-vascular volume to total placental volume). Statistical comparisons were drawn using tests for related samples (longitudinal data) or one-way analysis of variance (cross-sectional data). We found no significant differences in magnetization transfer between gestational age groups or between uncomplicated pregnancies and pregnancies complicated by pre-eclampsia or intrauterine growth restriction. In comparable groups of different subjects, stereological analyses also failed to demonstrate significant differences in residual:total volume ratios. We conclude that [a] the ratio of non-vascular volume:total placental volume does not alter between 16 and 36 weeks of normal gestation, and [b] this integrated response is also conserved in pre-eclampsia and intrauterine growth restriction. |
| spellingShingle | Ong, S Tyler, D Moore, R Gowland, P Baker, P Johnson, I Mayhew, T Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title | Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title_full | Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title_fullStr | Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title_full_unstemmed | Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title_short | Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction. |
| title_sort | functional magnetic resonance imaging magnetization transfer and stereological analysis of human placentae in normal pregnancy and in pre eclampsia and intrauterine growth restriction |
| work_keys_str_mv | AT ongs functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT tylerd functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT moorer functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT gowlandp functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT bakerp functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT johnsoni functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction AT mayhewt functionalmagneticresonanceimagingmagnetizationtransferandstereologicalanalysisofhumanplacentaeinnormalpregnancyandinpreeclampsiaandintrauterinegrowthrestriction |