Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.

Cardiac myocytes have provided a key paradigm for the concept of the compartmentalized cAMP generation sensed by AKAP-anchored PKA. Phosphodiesterases (PDEs) provide the sole route for degrading cAMP in cells and are thus poised to regulate intracellular cAMP gradients. PDE3 and PDE4 represent the m...

Bibliográfalaš dieđut
Váldodahkkit:	Mongillo, M, McSorley, T, Evellin, S, Sood, A, Lissandron, V, Terrin, A, Huston, E, Hannawacker, A, Lohse, M, Pozzan, T, Houslay, MD, Zaccolo, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2004

Geahča maid

Measuring dynamic changes in cAMP using fluorescence resonance energy transfer.
Dahkki: Evellin, S, et al.
Almmustuhtton: (2004)

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Dahkki: Mongillo, M, et al.
Almmustuhtton: (2006)

Phosphodiesterases and compartmentalized cAMP signalling in the heart.
Dahkki: Zaccolo, M
Almmustuhtton: (2006)

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.
Dahkki: Stangherlin, A, et al.
Almmustuhtton: (2012)

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
Dahkki: Terrin, A, et al.
Almmustuhtton: (2006)

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.
Dahkki: Lissandron, V, et al.
Almmustuhtton: (2006)

Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2006)

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling.
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2006)

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2002)

Imaging the cAMP-dependent signal transduction pathway
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2005)

Imaging the cAMP-dependent signal transduction pathway.
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2005)

Study of cyclic adenosine monophosphate microdomains in cells.
Dahkki: Mongillo, M, et al.
Almmustuhtton: (2005)

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
Dahkki: Koschinski, A, et al.
Almmustuhtton: (2017)

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
Dahkki: Wilson, L, et al.
Almmustuhtton: (2011)

Analysis of compartmentalized cAMP: A method to compare signals from differently targeted FRET reporters
Dahkki: Stangherlin, A, et al.
Almmustuhtton: (2014)

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.
Dahkki: Stangherlin, A, et al.
Almmustuhtton: (2014)

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.
Dahkki: Oliveira, R, et al.
Almmustuhtton: (2010)

β-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor
Dahkki: Warrier, S, et al.
Almmustuhtton: (2005)

Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.
Dahkki: Warrier, S, et al.
Almmustuhtton: (2005)

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Dahkki: Sin, Y, et al.
Almmustuhtton: (2011)

Compartmentalisation of cAMP and Ca(2+) signals.
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2002)

Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction.
Dahkki: Lissandron, V, et al.
Almmustuhtton: (2005)

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology.
Dahkki: Zaccolo, M, et al.
Almmustuhtton: (2007)

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
Dahkki: Monterisi, S, et al.
Almmustuhtton: (2013)

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.
Dahkki: Lomas, O, et al.
Almmustuhtton: (2014)

Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes
Dahkki: Fields, L, et al.
Almmustuhtton: (2015)

Role of membrane microdomains in compartmentation of cAMP signaling.
Dahkki: Shailesh R Agarwal, et al.
Almmustuhtton: (2014-01-01)

A toolkit for real-time detection of cAMP: insights into compartmentalized signaling.
Dahkki: Berrera, M, et al.
Almmustuhtton: (2008)

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes
Dahkki: Shailesh R. Agarwal, et al.
Almmustuhtton: (2018-04-01)

cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.
Dahkki: Stangherlin, A, et al.
Almmustuhtton: (2012)

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.
Dahkki: Rodrigo F Oliveira, et al.
Almmustuhtton: (2010-07-01)

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
Dahkki: Stangherlin, A, et al.
Almmustuhtton: (2011)

Modulation of compartmentalized cyclic nucleotide signalling via local inhibition of phosphodiesterase activity
Dahkki: Brescia, M, et al.
Almmustuhtton: (2016)

A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes
Dahkki: Mongillo, M, et al.
Almmustuhtton: (2006)

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.
Dahkki: Mongillo, M, et al.
Almmustuhtton: (2006)

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
Dahkki: Huston, E, et al.
Almmustuhtton: (1997)

Phosphodiesterases and cAMP Pathway in Pituitary Diseases
Dahkki: Mariana Ferreira Bizzi, et al.
Almmustuhtton: (2019-03-01)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
Dahkki: Martina Schmidt, et al.
Almmustuhtton: (2012-11-01)

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics
Dahkki: Simon J MacKenzie
Almmustuhtton: (2004-01-01)

Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts
Dahkki: Wright, PT, et al.
Almmustuhtton: (2018)