Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.

Cardiac myocytes have provided a key paradigm for the concept of the compartmentalized cAMP generation sensed by AKAP-anchored PKA. Phosphodiesterases (PDEs) provide the sole route for degrading cAMP in cells and are thus poised to regulate intracellular cAMP gradients. PDE3 and PDE4 represent the m...

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Detalles Bibliográficos
Main Authors: Mongillo, M, McSorley, T, Evellin, S, Sood, A, Lissandron, V, Terrin, A, Huston, E, Hannawacker, A, Lohse, M, Pozzan, T, Houslay, MD, Zaccolo, M
Formato: Journal article
Idioma:English
Publicado: 2004

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