Sex-specific differences in patients with psoriatic arthritis: a systematic review
<p><strong>Objective:</strong> A systematic review of published literature was conducted to collate evidence on sex-specific differences in clinical characteristics, disease activity, and patient-reported outcomes (PROs) in psoriatic arthritis (PsA), including response to...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Journal of Rheumatology
2022
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| _version_ | 1797111331120218112 |
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| author | Coates, LC van der Horst-Bruinsma, I Lubrano, E Beaver, S Drane, E Ufuktepe, B Ogdie-Beatty, A |
| author_facet | Coates, LC van der Horst-Bruinsma, I Lubrano, E Beaver, S Drane, E Ufuktepe, B Ogdie-Beatty, A |
| author_sort | Coates, LC |
| collection | OXFORD |
| description | <p><strong>Objective:</strong> A systematic review of published literature was conducted to collate evidence on sex-specific differences in clinical characteristics, disease activity, and patient-reported outcomes (PROs) in psoriatic arthritis (PsA), including response to treatment.</p>
<p><strong>Methods:</strong> Searches of MEDLINE, Embase, and the Cochrane Database of Systematic Reviews were performed in November 2020 for observational studies of adults with PsA reporting outcomes by sex (published from January 1, 2015, to November 13, 2020). In addition, hand searches of systematic literature reviews and (network) metaanalysis bibliographies were performed. Searches of ClinicalTrials.gov and congress abstracts from the European Alliance of Associations for Rheumatology, the American College of Rheumatology (ACR), and the American Academy of Dermatology (2019-2020) were also carried out. Eligible studies with 100 or more patients prespecified a comparison by sex and reported clinical characteristics and/or disease activity. Data extracted included patient characteristics, study design, baseline clinical characteristics, and disease activity results, including PROs.</p>
<p><strong>Results:</strong> Database searching yielded 3283 unique records; 31 publications of 27 unique studies were included. The review found generally higher rates of peripheral disease in women, including higher tender joint counts. There was some evidence of more axial disease in men, plus greater skin disease burden. There were consistently no differences in Dermatology Life Quality Index scores, though across other PROs, women had worse scores, including pain and fatigue. Women had poorer responses to treatment, indicated by outcome measures such as ACR responses and minimal disease activity.</p>
<p><strong>Conclusion:</strong> This review indicates that important differences exist between the sexes in PsA. However, the limited evidence for this conclusion underlines the need for additional research in this area.</p> |
| first_indexed | 2024-03-07T08:07:16Z |
| format | Journal article |
| id | oxford-uuid:df0c8b20-7b55-4452-994f-7f5ba725f323 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:07:16Z |
| publishDate | 2022 |
| publisher | Journal of Rheumatology |
| record_format | dspace |
| spelling | oxford-uuid:df0c8b20-7b55-4452-994f-7f5ba725f3232023-11-02T10:48:35ZSex-specific differences in patients with psoriatic arthritis: a systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:df0c8b20-7b55-4452-994f-7f5ba725f323EnglishSymplectic ElementsJournal of Rheumatology2022Coates, LCvan der Horst-Bruinsma, ILubrano, EBeaver, SDrane, EUfuktepe, BOgdie-Beatty, A<p><strong>Objective:</strong> A systematic review of published literature was conducted to collate evidence on sex-specific differences in clinical characteristics, disease activity, and patient-reported outcomes (PROs) in psoriatic arthritis (PsA), including response to treatment.</p> <p><strong>Methods:</strong> Searches of MEDLINE, Embase, and the Cochrane Database of Systematic Reviews were performed in November 2020 for observational studies of adults with PsA reporting outcomes by sex (published from January 1, 2015, to November 13, 2020). In addition, hand searches of systematic literature reviews and (network) metaanalysis bibliographies were performed. Searches of ClinicalTrials.gov and congress abstracts from the European Alliance of Associations for Rheumatology, the American College of Rheumatology (ACR), and the American Academy of Dermatology (2019-2020) were also carried out. Eligible studies with 100 or more patients prespecified a comparison by sex and reported clinical characteristics and/or disease activity. Data extracted included patient characteristics, study design, baseline clinical characteristics, and disease activity results, including PROs.</p> <p><strong>Results:</strong> Database searching yielded 3283 unique records; 31 publications of 27 unique studies were included. The review found generally higher rates of peripheral disease in women, including higher tender joint counts. There was some evidence of more axial disease in men, plus greater skin disease burden. There were consistently no differences in Dermatology Life Quality Index scores, though across other PROs, women had worse scores, including pain and fatigue. Women had poorer responses to treatment, indicated by outcome measures such as ACR responses and minimal disease activity.</p> <p><strong>Conclusion:</strong> This review indicates that important differences exist between the sexes in PsA. However, the limited evidence for this conclusion underlines the need for additional research in this area.</p> |
| spellingShingle | Coates, LC van der Horst-Bruinsma, I Lubrano, E Beaver, S Drane, E Ufuktepe, B Ogdie-Beatty, A Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title | Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title_full | Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title_fullStr | Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title_full_unstemmed | Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title_short | Sex-specific differences in patients with psoriatic arthritis: a systematic review |
| title_sort | sex specific differences in patients with psoriatic arthritis a systematic review |
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