Structural basis for Smoothened regulation by its extracellular domains
Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the membrane by Frizzled-class G-protein coupled receptors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (CRD). How such large extracellular domains of GPC...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Publishing Group
2016
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