Antidepressant response and the serotonin transporter gene-linked polymorphic region
Background: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been proposed as a predictor of antidepressant response. Insertion or deletion of a 44bp long region gives rise to short 'S' and long 'L' forms of the promoter region, the 'S' form being...
| मुख्य लेखकों: | , , |
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| अन्य लेखक: | |
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2010
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| विषय: |
| _version_ | 1826300735603605504 |
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| author | Taylor, M Sen, S Bhagwagar, Z |
| author2 | Society of Biological Psychiatry |
| author_facet | Society of Biological Psychiatry Taylor, M Sen, S Bhagwagar, Z |
| author_sort | Taylor, M |
| collection | OXFORD |
| description | Background: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been proposed as a predictor of antidepressant response. Insertion or deletion of a 44bp long region gives rise to short 'S' and long 'L' forms of the promoter region, the 'S' form being associated with reduced serotonin transporter expression. Methods: A systematic review and meta-analysis was performed to clarify the effect of 5-HTTLPR on antidepressant response and remission rates. Data were obtained from 28 studies with 5408 participants. Three genotype comparisons were tested - SS versus (SL or LL), (SS or SL) versus LL, and SS versus LL. Results: There was no statistically significant effect on antidepressant response. Compared to L carriers, there was an apparent effect of the SS genotype on remission rate (RR 0.88; 95% CI 0.79 to 0.98; p=0.02). However, after trim and fill correction for missing data, the effect disappeared (RR 0.92; 95% CI 0.81 to 1.05; p=0.23) indicating that the initial significant effect was likely the result of publication bias. No significant effect on remission rate was seen for SS versus LL and SS/SL versus LL. Substantial unexplained heterogeneity of effect sizes was observed between studies, pointing to additional interacting factors contributing to an association in some cases. Conclusions: The 5-HTTLPR biallelic short/long polymorphism by itself does not appear to usefully predict antidepressant response. |
| first_indexed | 2024-03-07T05:21:41Z |
| format | Journal article |
| id | oxford-uuid:df23587c-b150-4a69-a0ff-c93ae3135d82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:21:41Z |
| publishDate | 2010 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:df23587c-b150-4a69-a0ff-c93ae3135d822022-03-27T09:37:17ZAntidepressant response and the serotonin transporter gene-linked polymorphic region Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:df23587c-b150-4a69-a0ff-c93ae3135d82Evidence based mental healthPsychopharmacologyEnglishOxford University Research Archive - ValetElsevier2010Taylor, MSen, SBhagwagar, ZSociety of Biological PsychiatryBackground: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been proposed as a predictor of antidepressant response. Insertion or deletion of a 44bp long region gives rise to short 'S' and long 'L' forms of the promoter region, the 'S' form being associated with reduced serotonin transporter expression. Methods: A systematic review and meta-analysis was performed to clarify the effect of 5-HTTLPR on antidepressant response and remission rates. Data were obtained from 28 studies with 5408 participants. Three genotype comparisons were tested - SS versus (SL or LL), (SS or SL) versus LL, and SS versus LL. Results: There was no statistically significant effect on antidepressant response. Compared to L carriers, there was an apparent effect of the SS genotype on remission rate (RR 0.88; 95% CI 0.79 to 0.98; p=0.02). However, after trim and fill correction for missing data, the effect disappeared (RR 0.92; 95% CI 0.81 to 1.05; p=0.23) indicating that the initial significant effect was likely the result of publication bias. No significant effect on remission rate was seen for SS versus LL and SS/SL versus LL. Substantial unexplained heterogeneity of effect sizes was observed between studies, pointing to additional interacting factors contributing to an association in some cases. Conclusions: The 5-HTTLPR biallelic short/long polymorphism by itself does not appear to usefully predict antidepressant response. |
| spellingShingle | Evidence based mental health Psychopharmacology Taylor, M Sen, S Bhagwagar, Z Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title | Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title_full | Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title_fullStr | Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title_full_unstemmed | Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title_short | Antidepressant response and the serotonin transporter gene-linked polymorphic region |
| title_sort | antidepressant response and the serotonin transporter gene linked polymorphic region |
| topic | Evidence based mental health Psychopharmacology |
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