Germs, genomes and genealogies.
Genetic diversity in pathogen species contains information about evolutionary and epidemiological processes, including the origins and history of disease, the nature of the selective forces acting on pathogen genes and the role of recombination in generating genetic novelty. Here, we review recent d...
| Hoofdauteurs: | , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2005
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| _version_ | 1826300738721021952 |
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| author | Wilson, D Falush, D McVean, G |
| author_facet | Wilson, D Falush, D McVean, G |
| author_sort | Wilson, D |
| collection | OXFORD |
| description | Genetic diversity in pathogen species contains information about evolutionary and epidemiological processes, including the origins and history of disease, the nature of the selective forces acting on pathogen genes and the role of recombination in generating genetic novelty. Here, we review recent developments in these fields and compare the use of population genetic, or population-model based, approaches to phylogenetic, or population-model free, methodologies. We show how simple epidemiological models can be related to the ancestral, or coalescent, process underlying samples from pathogen species, enabling detailed inference about pathogen biology from patterns of molecular variation. |
| first_indexed | 2024-03-07T05:21:45Z |
| format | Journal article |
| id | oxford-uuid:df268f12-e008-42d5-b1f5-5cf0a0a3b81f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:21:45Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:df268f12-e008-42d5-b1f5-5cf0a0a3b81f2022-03-27T09:37:23ZGerms, genomes and genealogies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:df268f12-e008-42d5-b1f5-5cf0a0a3b81fEnglishSymplectic Elements at Oxford2005Wilson, DFalush, DMcVean, GGenetic diversity in pathogen species contains information about evolutionary and epidemiological processes, including the origins and history of disease, the nature of the selective forces acting on pathogen genes and the role of recombination in generating genetic novelty. Here, we review recent developments in these fields and compare the use of population genetic, or population-model based, approaches to phylogenetic, or population-model free, methodologies. We show how simple epidemiological models can be related to the ancestral, or coalescent, process underlying samples from pathogen species, enabling detailed inference about pathogen biology from patterns of molecular variation. |
| spellingShingle | Wilson, D Falush, D McVean, G Germs, genomes and genealogies. |
| title | Germs, genomes and genealogies. |
| title_full | Germs, genomes and genealogies. |
| title_fullStr | Germs, genomes and genealogies. |
| title_full_unstemmed | Germs, genomes and genealogies. |
| title_short | Germs, genomes and genealogies. |
| title_sort | germs genomes and genealogies |
| work_keys_str_mv | AT wilsond germsgenomesandgenealogies AT falushd germsgenomesandgenealogies AT mcveang germsgenomesandgenealogies |