Biophysical characterization of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostructures, and high potential for flexible programma...

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Bibliographic Details
Main Authors: Miller, HL, Antoranz Contera, S, Wollman, AJM, Hirst, A, Dunn, KE, Schröeter, S, O'Connell, D, Leake, MC
Format: Journal article
Language:English
Published: IOP Publishing 2020