Proton-assisted Amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subseq...

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Hlavní autoři:	Ögmundsdóttir, M, Heublein, S, Kazi, S, Reynolds, B, Visvalingam, S, Shaw, M, Goberdhan, D
Médium:	Journal article
Jazyk:	English
Vydáno:	2012

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes Autor Ögmundsdóttir, M, Heublein, S, Kazi, S, Reynolds, B, Visvalingam, S, Shaw, M, Goberdhan, D

Vydáno 2012

Journal article

Proton-assisted Amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes Autor Ögmundsdóttir, M, Heublein, S, Kazi, S, Reynolds, B, Visvalingam, S, Shaw, M, Goberdhan, D

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