Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition.
β-Lactams inhibit penicillin-binding proteins (PBPs) and serine β-lactamases by acylation of a nucleophilic active site serine. Avibactam is approved for clinical use in combination with ceftazidime, and is a breakthrough non β-lactam β-lactamase inhibitor also reacting via serine acylation. Molecul...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2016
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