NKCC1 deficiency in forming hippocampal circuits triggers neurodevelopmental disorder: Role of BDNF-TrkB signalling
The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2. NKCC1, encoded by the SLC12A2 gene, regulates neuronal Cl− homeostasis by chloride impo...
| Hlavní autoři: | , |
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| Médium: | Journal article |
| Jazyk: | English |
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MDPI
2022
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