Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2008

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
‌: Artz, J, և այլն
Հրապարակվել է: (2008)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
‌: Dunford, J, և այլն
Հրապարակվել է: (2006)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
‌: Dunford, J, և այլն
Հրապարակվել է: (2006)

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.
‌: Dunford, J
Հրապարակվել է: (2010)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2005)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
‌: Dunford, J, և այլն
Հրապարակվել է: (2007)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates
‌: Dunford, J, և այլն
Հրապարակվել է: (2008)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
‌: Dunford, J, և այլն
Հրապարակվել է: (2008)

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
‌: Kwassi, A, և այլն
Հրապարակվել է: (2009)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
‌: Dunford, J, և այլն
Հրապարակվել է: (2008)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
‌: Evdokimov, A, և այլն
Հրապարակվել է: (2006)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
‌: Dunford, J, և այլն
Հրապարակվել է: (2008)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2002)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
‌: Dunford, J, և այլն
Հրապարակվել է: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
‌: Dunford, J, և այլն
Հրապարակվել է: (2007)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2006)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
‌: Xia, Z, և այլն
Հրապարակվել է: (2007)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2007)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
‌: Ebetino, F, և այլն
Հրապարակվել է: (2002)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2005)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
‌: Ebetino, F, և այլն
Հրապարակվել է: (2002)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
‌: Tsoumpra, M, և այլն
Հրապարակվել է: (2010)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2008)

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
‌: Xia, Z, և այլն
Հրապարակվել է: (2007)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2006)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
‌: Hogan, J, և այլն
Հրապարակվել է: (2007)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
‌: Ebetino, F, և այլն
Հրապարակվել է: (2007)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
‌: Tsoumpra, M, և այլն
Հրապարակվել է: (2015)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2006)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
‌: Tsoumpra, MK, և այլն
Հրապարակվել է: (2015)

Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinities
‌: Xia, Z, և այլն
Հրապարակվել է: (2007)

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
‌: Artz, J, և այլն
Հրապարակվել է: (2011)

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
‌: Russell, R, և այլն
Հրապարակվել է: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
‌: Ebetino, F, և այլն
Հրապարակվել է: (2006)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
‌: Xia, Z, և այլն
Հրապարակվել է: (2006)

Differences between bisphosphonates in binding affinities for hydroxyapatite.
‌: Lawson, M, և այլն
Հրապարակվել է: (2010)

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.
‌: Kavanagh, K, և այլն
Հրապարակվել է: (2006)

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Նմանատիպ նյութեր

Նմանատիպ նյութեր