Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

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Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...

书目详细资料
Main Authors:	Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
格式:	Journal article
语言:	English
出版:	2008

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