Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease

A series of iminosugars bearing two or three alkyl chains ('iminoglycolipids') were designed as ceramide mimics and analogues of N-butyl 1-deoxynojirimycin (N-Bu DNJ, Zavesca®). This orally active iminosugar inhibits the biosynthesis of glucosylceramides, which accumulate pathologically in...

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Bibliografiske detaljer
Main Authors:	Boucheron, C, Desvergnes, V, Compain, P, Martin, O, Lavi, A, Mackeen, M, Wormald, M, Dwek, R, Butters, T
Format:	Journal article
Sprog:	English
Udgivet:	2005

Lignende værker

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease (vol 16, pg 1747, 2005)
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Erratum: Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: The search for new therapeutic agents against Gaucher disease (Tetrahedron: Asymmetry (2005) 16 (1747) DOI: 10.1016/j.tetasy.2005.03. 015)
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