Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease
A series of iminosugars bearing two or three alkyl chains ('iminoglycolipids') were designed as ceramide mimics and analogues of N-butyl 1-deoxynojirimycin (N-Bu DNJ, Zavesca®). This orally active iminosugar inhibits the biosynthesis of glucosylceramides, which accumulate pathologically in...
Հիմնական հեղինակներ: | Boucheron, C, Desvergnes, V, Compain, P, Martin, O, Lavi, A, Mackeen, M, Wormald, M, Dwek, R, Butters, T |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2005
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Նմանատիպ նյութեր
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Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease (vol 16, pg 1747, 2005)
: Boucheron, C, և այլն
Հրապարակվել է: (2005) -
Erratum: Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: The search for new therapeutic agents against Gaucher disease (Tetrahedron: Asymmetry (2005) 16 (1747) DOI: 10.1016/j.tetasy.2005.03. 015)
: Boucheron, C, և այլն
Հրապարակվել է: (2005) -
Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?
: Norris-Cervetto, E, և այլն
Հրապարակվել է: (2006) -
Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors
: Cécile Baudoin-Dehoux, և այլն
Հրապարակվել է: (2019-01-01) -
Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
: Karen M Ashe, և այլն
Հրապարակվել է: (2011-01-01)