Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

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To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487...

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Détails bibliographiques
Auteurs principaux: Broderick, P, Chubb, D, Johnson, D, Weinhold, N, Försti, A, Lloyd, A, Olver, B, Ma, Y, Dobbins, SE, Walker, B, Davies, F, Gregory, W, Child, J, Ross, F, Jackson, G, Neben, K, Jauch, A, Hoffmann, P, Mühleisen, T, Nöthen, M, Moebus, S, Tomlinson, I, Goldschmidt, H, Hemminki, K, Morgan, G
Format: Journal article
Langue:English
Publié: 2012
Description
Résumé:To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

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