Transcriptional regulator PRDM12 is essential for human pain perception
Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments1,2. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal3,4. New therapeutic o...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2015
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| _version_ | 1826300850291605504 |
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| author | Chen, Y Auer-Grumbach, M Matsukawa, S Themistocleous, A Schmid, A Bennett, D al., E |
| author_facet | Chen, Y Auer-Grumbach, M Matsukawa, S Themistocleous, A Schmid, A Bennett, D al., E |
| author_sort | Chen, Y |
| collection | OXFORD |
| description | Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments1,2. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal3,4. New therapeutic options have recently been derived from studies of individuals with congenital insensitivity to pain (CIP)5,6. Here we identified 10 different homozygous mutations in PRDM12 (encoding PRDI-BF1 and RIZ homology domain-containing protein 12) in subjects with CIP from 11 families. Prdm proteins are a family of epigenetic regulators that control neural specification and neurogenesis7,8. We determined that Prdm12 is expressed in nociceptors and their progenitors and participates in the development of sensory neurons in Xenopus embryos. Moreover, CIP-associated mutants abrogate the histone-modifying potential associated with wild-type Prdm12. Prdm12 emerges as a key factor in the orchestration of sensory neurogenesis and may hold promise as a target for new pain therapeutics |
| first_indexed | 2024-03-07T05:23:25Z |
| format | Journal article |
| id | oxford-uuid:dfb73a9b-0ac0-411e-91ac-928e4fd270a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:23:25Z |
| publishDate | 2015 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:dfb73a9b-0ac0-411e-91ac-928e4fd270a22022-03-27T09:41:23ZTranscriptional regulator PRDM12 is essential for human pain perceptionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dfb73a9b-0ac0-411e-91ac-928e4fd270a2EnglishSymplectic Elements at OxfordNature Research2015Chen, YAuer-Grumbach, MMatsukawa, SThemistocleous, ASchmid, ABennett, Dal., EPain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments1,2. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal3,4. New therapeutic options have recently been derived from studies of individuals with congenital insensitivity to pain (CIP)5,6. Here we identified 10 different homozygous mutations in PRDM12 (encoding PRDI-BF1 and RIZ homology domain-containing protein 12) in subjects with CIP from 11 families. Prdm proteins are a family of epigenetic regulators that control neural specification and neurogenesis7,8. We determined that Prdm12 is expressed in nociceptors and their progenitors and participates in the development of sensory neurons in Xenopus embryos. Moreover, CIP-associated mutants abrogate the histone-modifying potential associated with wild-type Prdm12. Prdm12 emerges as a key factor in the orchestration of sensory neurogenesis and may hold promise as a target for new pain therapeutics |
| spellingShingle | Chen, Y Auer-Grumbach, M Matsukawa, S Themistocleous, A Schmid, A Bennett, D al., E Transcriptional regulator PRDM12 is essential for human pain perception |
| title | Transcriptional regulator PRDM12 is essential for human pain perception |
| title_full | Transcriptional regulator PRDM12 is essential for human pain perception |
| title_fullStr | Transcriptional regulator PRDM12 is essential for human pain perception |
| title_full_unstemmed | Transcriptional regulator PRDM12 is essential for human pain perception |
| title_short | Transcriptional regulator PRDM12 is essential for human pain perception |
| title_sort | transcriptional regulator prdm12 is essential for human pain perception |
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