The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
PREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine midlife risk factors for dementia and identify and describe the earliest indices of disease development. The PREVENT dementia programme is one of the original epidemiological initiatives targeting midlife a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2024
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| _version_ | 1811139661380190208 |
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| author | Ritchie, CW Bridgeman, K Gregory, S O’Brien, JT Danso, SO Dounavi, M Carriere, I Driscoll, D Hillary, R Koychev, I Lawlor, B Naci, L Su, L Low, A Mak, E Malhotra, P Manson, J Marioni, R Murphy, L Ntailianis, G Stewart, W Muniz-Terrera, G Ritchie, K |
| author_facet | Ritchie, CW Bridgeman, K Gregory, S O’Brien, JT Danso, SO Dounavi, M Carriere, I Driscoll, D Hillary, R Koychev, I Lawlor, B Naci, L Su, L Low, A Mak, E Malhotra, P Manson, J Marioni, R Murphy, L Ntailianis, G Stewart, W Muniz-Terrera, G Ritchie, K |
| author_sort | Ritchie, CW |
| collection | OXFORD |
| description | PREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine midlife risk factors for dementia and identify and describe the earliest indices of disease development. The PREVENT dementia programme is one of the original epidemiological initiatives targeting midlife as a critical window for intervention in neurodegenerative conditions. This paper provides an overview of the study protocol and presents the first summary results from the initial baseline data to describe the cohort. Participants in the PREVENT cohort provide demographic data, biological samples (blood, saliva, urine and optional cerebrospinal fluid), lifestyle and psychological questionnaires, undergo a comprehensive cognitive test battery and are imaged using multi-modal 3-T MRI scanning, with both structural and functional sequences. The PREVENT cohort governance structure is described, which includes a steering committee, a scientific advisory board and core patient and public involvement groups. A number of sub-studies that supplement the main PREVENT cohort are also described. The PREVENT cohort baseline data include 700 participants recruited between 2014 and 2020 across five sites in the UK and Ireland (Cambridge, Dublin, Edinburgh, London and Oxford). At baseline, participants had a mean age of 51.2 years (range 40–59, SD ± 5.47), with the majority female (n = 433, 61.9%). There was a near equal distribution of participants with and without a parental history of dementia (51.4% versus 48.6%) and a relatively high prevalence of APOEɛ4 carriers (n = 264, 38.0%). Participants were highly educated (16.7 ± 3.44 years of education), were mainly of European Ancestry (n = 672, 95.9%) and were cognitively healthy as measured by the Addenbrookes Cognitive Examination-III (total score 95.6 ± 4.06). Mean white matter hyperintensity volume at recruitment was 2.26 ± 2.77 ml (median = 1.39 ml), with hippocampal volume being 8.15 ± 0.79 ml. There was good representation of known dementia risk factors in the cohort. The PREVENT cohort offers a novel data set to explore midlife risk factors and early signs of neurodegenerative disease. Data are available open access at no cost via the Alzheimer’s Disease Data Initiative platform and Dementia Platforms UK platform pending approval of the data access request from the PREVENT steering group committee. |
| first_indexed | 2024-09-25T04:09:38Z |
| format | Journal article |
| id | oxford-uuid:dfd2a985-48fb-44bd-875b-1ff1ac15d650 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:09:38Z |
| publishDate | 2024 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:dfd2a985-48fb-44bd-875b-1ff1ac15d6502024-06-11T20:13:39ZThe PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:dfd2a985-48fb-44bd-875b-1ff1ac15d650EnglishJisc Publications RouterOxford University Press2024Ritchie, CWBridgeman, KGregory, SO’Brien, JTDanso, SODounavi, MCarriere, IDriscoll, DHillary, RKoychev, ILawlor, BNaci, LSu, LLow, AMak, EMalhotra, PManson, JMarioni, RMurphy, LNtailianis, GStewart, WMuniz-Terrera, GRitchie, KPREVENT is a multi-centre prospective cohort study in the UK and Ireland that aims to examine midlife risk factors for dementia and identify and describe the earliest indices of disease development. The PREVENT dementia programme is one of the original epidemiological initiatives targeting midlife as a critical window for intervention in neurodegenerative conditions. This paper provides an overview of the study protocol and presents the first summary results from the initial baseline data to describe the cohort. Participants in the PREVENT cohort provide demographic data, biological samples (blood, saliva, urine and optional cerebrospinal fluid), lifestyle and psychological questionnaires, undergo a comprehensive cognitive test battery and are imaged using multi-modal 3-T MRI scanning, with both structural and functional sequences. The PREVENT cohort governance structure is described, which includes a steering committee, a scientific advisory board and core patient and public involvement groups. A number of sub-studies that supplement the main PREVENT cohort are also described. The PREVENT cohort baseline data include 700 participants recruited between 2014 and 2020 across five sites in the UK and Ireland (Cambridge, Dublin, Edinburgh, London and Oxford). At baseline, participants had a mean age of 51.2 years (range 40–59, SD ± 5.47), with the majority female (n = 433, 61.9%). There was a near equal distribution of participants with and without a parental history of dementia (51.4% versus 48.6%) and a relatively high prevalence of APOEɛ4 carriers (n = 264, 38.0%). Participants were highly educated (16.7 ± 3.44 years of education), were mainly of European Ancestry (n = 672, 95.9%) and were cognitively healthy as measured by the Addenbrookes Cognitive Examination-III (total score 95.6 ± 4.06). Mean white matter hyperintensity volume at recruitment was 2.26 ± 2.77 ml (median = 1.39 ml), with hippocampal volume being 8.15 ± 0.79 ml. There was good representation of known dementia risk factors in the cohort. The PREVENT cohort offers a novel data set to explore midlife risk factors and early signs of neurodegenerative disease. Data are available open access at no cost via the Alzheimer’s Disease Data Initiative platform and Dementia Platforms UK platform pending approval of the data access request from the PREVENT steering group committee. |
| spellingShingle | Ritchie, CW Bridgeman, K Gregory, S O’Brien, JT Danso, SO Dounavi, M Carriere, I Driscoll, D Hillary, R Koychev, I Lawlor, B Naci, L Su, L Low, A Mak, E Malhotra, P Manson, J Marioni, R Murphy, L Ntailianis, G Stewart, W Muniz-Terrera, G Ritchie, K The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title | The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title_full | The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title_fullStr | The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title_full_unstemmed | The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title_short | The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
| title_sort | prevent dementia programme baseline demographic lifestyle imaging and cognitive data from a midlife cohort study investigating risk factors for dementia |
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