Asymmetric synthesis of beta-amino-gamma-substituted-gamma-butyrolactones: double diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters.

Chiral alpha,beta-unsaturated esters, containing a single, gamma-stereogenic centre, show modest levels of substrate control upon conjugate addition of lithium dibenzylamide. Double diastereoselective conjugate additions of homochiral lithium N-benzyl-N-(alpha-methylbenzyl)amide to the homochiral al...

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書目詳細資料
Main Authors: Cailleau, T, Cooke, J, Davies, S, Ling, K, Naylor, A, Nicholson, R, Price, P, Roberts, P, Russell, A, Smith, A, Thomson, J
格式: Journal article
語言:English
出版: 2007