Structural explanation for the role of Mn^2+ in the activity of Φ6 RNA-dependent RNA polymerase
The biological role of manganese (MN^2+) has been a long-standing puzzle, since at low concentrations it activates several polymerases whilst at higher concentrations it inhibits. Viral RNA polymerases possess a common architecture, reminiscent of a closed right hand. The RNA-dependent RNA polymeras...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2008
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| Subjects: |