Modulation of proteolysis counteracts oxidative stress but impairs base excision repair in ATM-depleted cells
<p>Ataxia-telangiectasia (A-T), also known as Louis-Bar syndrome, is a neurodegenerative autosomal recessive disease caused by bi-allelic mutations in the ataxia-telangiectasia mutated (ATM) gene. The product of the ATM gene is a serine/threonine kinase that acts as primary mediator of cellula...
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2017
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