The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which tr...

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Detalles Bibliográficos
Main Authors: Ratsimandresy, R, Chu, L, Khare, S, de Almeida, L, Gangopadhyay, A, Indramohan, M, Misharin, A, Greaves, D, Perlman, H, Dorfleutner, A, Stehlik, C
Formato: Journal article
Idioma:English
Publicado: Nature Publishing Group 2017

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