Diagnosis and management of the neurological complications of falciparum malaria.
Malaria is a major public health problem in the developing world owing to its high rates of morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium falciparum is most commonly associated with neurological complications, which manifest as agitation, psychosis, seizures,...
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797099482993655808 |
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| author | Mishra, S Newton, C |
| author_facet | Mishra, S Newton, C |
| author_sort | Mishra, S |
| collection | OXFORD |
| description | Malaria is a major public health problem in the developing world owing to its high rates of morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium falciparum is most commonly associated with neurological complications, which manifest as agitation, psychosis, seizures, impaired consciousness and coma (cerebral malaria). Cerebral malaria is the most severe neurological complication; the condition is associated with mortality of 15-20%, and a substantial proportion of individuals with this condition develop neurocognitive sequelae. In this Review, we describe the various neurological complications encountered in malaria, discuss the underlying pathogenesis, and outline current management strategies for these complications. Furthermore, we discuss the role of adjunctive therapies in improving outcome. |
| first_indexed | 2024-03-07T05:24:22Z |
| format | Journal article |
| id | oxford-uuid:e00b8a99-b6dc-4d27-bf7b-78c868f92f72 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:24:22Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:e00b8a99-b6dc-4d27-bf7b-78c868f92f722022-03-27T09:43:57ZDiagnosis and management of the neurological complications of falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e00b8a99-b6dc-4d27-bf7b-78c868f92f72EnglishSymplectic Elements at Oxford2009Mishra, SNewton, CMalaria is a major public health problem in the developing world owing to its high rates of morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium falciparum is most commonly associated with neurological complications, which manifest as agitation, psychosis, seizures, impaired consciousness and coma (cerebral malaria). Cerebral malaria is the most severe neurological complication; the condition is associated with mortality of 15-20%, and a substantial proportion of individuals with this condition develop neurocognitive sequelae. In this Review, we describe the various neurological complications encountered in malaria, discuss the underlying pathogenesis, and outline current management strategies for these complications. Furthermore, we discuss the role of adjunctive therapies in improving outcome. |
| spellingShingle | Mishra, S Newton, C Diagnosis and management of the neurological complications of falciparum malaria. |
| title | Diagnosis and management of the neurological complications of falciparum malaria. |
| title_full | Diagnosis and management of the neurological complications of falciparum malaria. |
| title_fullStr | Diagnosis and management of the neurological complications of falciparum malaria. |
| title_full_unstemmed | Diagnosis and management of the neurological complications of falciparum malaria. |
| title_short | Diagnosis and management of the neurological complications of falciparum malaria. |
| title_sort | diagnosis and management of the neurological complications of falciparum malaria |
| work_keys_str_mv | AT mishras diagnosisandmanagementoftheneurologicalcomplicationsoffalciparummalaria AT newtonc diagnosisandmanagementoftheneurologicalcomplicationsoffalciparummalaria |