Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss
<p><strong>Background and aim: </strong>The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined.</p> <p><strong>Methods:</strong>&...
| Հիմնական հեղինակներ: | , , , , , , , , , |
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| Այլ հեղինակներ: | |
| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
BioMed Central
2022
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| _version_ | 1826310135643897856 |
|---|---|
| author | Vidal-Ostos, F Ramos-Lopez, O Jebb, SA Papadaki, A Pfeiffer, AFH Handjieva-Darlenska, T Kunešová, M Blaak, EE Astrup, A Martinez, JA |
| author2 | Diet, Obesity, and Genes (Diogenes) Project |
| author_facet | Diet, Obesity, and Genes (Diogenes) Project Vidal-Ostos, F Ramos-Lopez, O Jebb, SA Papadaki, A Pfeiffer, AFH Handjieva-Darlenska, T Kunešová, M Blaak, EE Astrup, A Martinez, JA |
| author_sort | Vidal-Ostos, F |
| collection | OXFORD |
| description | <p><strong>Background and aim: </strong>The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined.</p>
<p><strong>Methods:</strong> This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0–8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8–34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0–34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance.</p>
<p><strong>Results:</strong> In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (<em>p</em> < 0.05). ∆TyG was positively associated with resistance to BMI loss (β = 0.343, <em>p</em> = 0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8–34 weeks period (r = −0.256; <em>p</em> < 0.05) and during the 0–34 weeks intervention (r = −0.222, <em>p</em> < 0.05) periods. ΔTyG<sub>1</sub> value was associated with ΔBMI<sub>2</sub> (β = 0.932; <em>p</em> = 0.045) concerning the HP/LGI diet.</p>
<p><strong>Conclusions:</strong> A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but is also related to IR amelioration as assessed by TyG index changes. Registration Clinical Trials NCT00390637.</p> |
| first_indexed | 2024-03-07T07:46:09Z |
| format | Journal article |
| id | oxford-uuid:e01cc50d-cdd3-4ca8-ba67-4b74b7f23450 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:46:09Z |
| publishDate | 2022 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:e01cc50d-cdd3-4ca8-ba67-4b74b7f234502023-06-08T13:59:28ZDietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight lossJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e01cc50d-cdd3-4ca8-ba67-4b74b7f23450EnglishSymplectic ElementsBioMed Central2022Vidal-Ostos, FRamos-Lopez, OJebb, SAPapadaki, APfeiffer, AFHHandjieva-Darlenska, TKunešová, MBlaak, EEAstrup, AMartinez, JADiet, Obesity, and Genes (Diogenes) Project<p><strong>Background and aim: </strong>The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined.</p> <p><strong>Methods:</strong> This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0–8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8–34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0–34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance.</p> <p><strong>Results:</strong> In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (<em>p</em> < 0.05). ∆TyG was positively associated with resistance to BMI loss (β = 0.343, <em>p</em> = 0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8–34 weeks period (r = −0.256; <em>p</em> < 0.05) and during the 0–34 weeks intervention (r = −0.222, <em>p</em> < 0.05) periods. ΔTyG<sub>1</sub> value was associated with ΔBMI<sub>2</sub> (β = 0.932; <em>p</em> = 0.045) concerning the HP/LGI diet.</p> <p><strong>Conclusions:</strong> A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but is also related to IR amelioration as assessed by TyG index changes. Registration Clinical Trials NCT00390637.</p> |
| spellingShingle | Vidal-Ostos, F Ramos-Lopez, O Jebb, SA Papadaki, A Pfeiffer, AFH Handjieva-Darlenska, T Kunešová, M Blaak, EE Astrup, A Martinez, JA Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title | Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title_full | Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title_fullStr | Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title_full_unstemmed | Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title_short | Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss |
| title_sort | dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy restricted induced weight loss |
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