Structure and function of the PP2A-shugoshin interaction.

Structure and function of the PP2A-shugoshin interaction.

Accurate chromosome segregation during mitosis and meiosis depends on shugoshin proteins that prevent precocious dissociation of cohesin from centromeres. Shugoshins associate with PP2A, which is thought to dephosphorylate cohesin and thereby prevent cleavage by separase during meiosis I. A crystal...

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Bibliographic Details
Main Authors:	Xu, Z, Cetin, B, Anger, M, Cho, US, Helmhart, W, Nasmyth, K, Xu, W
Format:	Journal article
Language:	English
Published:	2009

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