Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti-cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin-C, may generate barriers for TIL. To investigate this possibility, we used a MMTV-...

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Những tác giả chính: Murdamoothoo, D, Sun, Z, Yilmaz, A, Deligne, C, Midwood, K
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Wiley Open Access 2021