T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

Genome-wide association studies have identified noncoding variants near TBX3 that are associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricular conduction system function. To explore whether and to what extent the atrioventricular conduct...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Mohan, RA, Bosada, FM, van Weerd, JH, van Duijvenboden, K, Wang, J, Mommersteeg, MTM, Hooijkaas, IB, Wakker, V, de Gier-de Vries, C, Coronel, R, Boink, GJJ, Bakkers, J, Barnett, P, Boukens, BJ, Christoffels, VM
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	National Academy of Sciences 2020

Eitemau Tebyg

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
gan: Bakker, M, et al.
Cyhoeddwyd: (2008)

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction
gan: Jan Hendrik van Weerd, et al.
Cyhoeddwyd: (2020-07-01)

Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.
gan: Aanhaanen, W, et al.
Cyhoeddwyd: (2010)

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction
gan: Mohan, R, et al.
Cyhoeddwyd: (2018)

Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm
gan: Timo Jonker, et al.
Cyhoeddwyd: (2023-12-01)

Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes
gan: Marie Günthel, et al.
Cyhoeddwyd: (2021-10-01)

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
gan: Fernanda M Bosada, et al.
Cyhoeddwyd: (2023-01-01)

A single cell transcriptional roadmap of human pacemaker cell differentiation
gan: Alexandra Wiesinger, et al.
Cyhoeddwyd: (2022-10-01)

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation
gan: Malou van den Boogaard, et al.
Cyhoeddwyd: (2019-09-01)

Talkin’ ‘bout regeneration: new advances in cardiac regeneration using the zebrafish
gan: Smith, KA, et al.
Cyhoeddwyd: (2020)

Identification and functional characterization of cardiac pacemaker cells in zebrafish.
gan: Federico Tessadori, et al.
Cyhoeddwyd: (2012-01-01)

Unlocking the secrets of the regenerating fish heart: comparing regenerative models to shed light on successful regeneration
gan: Potts, HG, et al.
Cyhoeddwyd: (2021)

Identification of atrial fibrillation associated genes and functional non-coding variants
gan: Antoinette F. van Ouwerkerk, et al.
Cyhoeddwyd: (2019-10-01)

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
gan: Jiuru Li, et al.
Cyhoeddwyd: (2022-10-01)

Transcriptional profiling of cells sorted by transcript abundance
gan: Klemm, Sandy Lee, et al.
Cyhoeddwyd: (2015)

Transcript counting in single cells reveals dynamics of rDNA transcription
gan: Tan, Rui Zhen, et al.
Cyhoeddwyd: (2011)

Transcript counting in single cells reveals dynamics of rDNA transcription
gan: Rui Zhen Tan, et al.
Cyhoeddwyd: (2010-04-01)

OccuPeak: ChIP-Seq peak calling based on internal background modelling.
gan: Bouke A de Boer, et al.
Cyhoeddwyd: (2014-01-01)

Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.
gan: Mommersteeg, M, et al.
Cyhoeddwyd: (2007)

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
gan: Joyce C. K. Man, et al.
Cyhoeddwyd: (2019-10-01)

Atrial fibrillation: a developmental point of view.
gan: Mommersteeg, M, et al.
Cyhoeddwyd: (2009)

A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription.
gan: Harm van Bakel, et al.
Cyhoeddwyd: (2013-05-01)

Investigations into transcription and transcripts in Saccharomyces cerevisiae
gan: Fischl, H
Cyhoeddwyd: (2015)

Transcriptional and Post-Transcriptional Regulation of Autophagy
gan: Qiuqin Ma, et al.
Cyhoeddwyd: (2022-01-01)

Transcription Factors in Cartilage Homeostasis and Osteoarthritis
gan: Margot Neefjes, et al.
Cyhoeddwyd: (2020-09-01)

Early Postnatal Cardiac Stress Does Not Influence Ventricular Cardiomyocyte Cell-Cycle Withdrawal
gan: Marie Günthel, et al.
Cyhoeddwyd: (2021-04-01)

Extraordinary model systems for regeneration
gan: Accorsi, A, et al.
Cyhoeddwyd: (2024)

Found: the elusive ANTAR transcription antiterminator.
gan: Valley Stewart, et al.
Cyhoeddwyd: (2012-01-01)

A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
gan: Estelle Plant, et al.
Cyhoeddwyd: (2023-06-01)

Transcriptional Response of Burkholderia cenocepacia H111 to Severe Zinc Starvation
gan: James Paul Barnett
Cyhoeddwyd: (2023-09-01)

Validating Transcripts with Probes and Imaging Technology
gan: Itzkovitz, Shaul Shalev, et al.
Cyhoeddwyd: (2012)

Transcription factor condensates and signaling driven transcription
gan: Rajat Mann, et al.
Cyhoeddwyd: (2023-12-01)

Transcriptional regulation by competing transcription factor modules.
gan: Rutger Hermsen, et al.
Cyhoeddwyd: (2006-12-01)

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
gan: Drake S. Edwards, et al.
Cyhoeddwyd: (2020-09-01)

Identification of transcription factors dictating blood cell development using a bidirectional transcription network-based computational framework
gan: B. M. H. Heuts, et al.
Cyhoeddwyd: (2022-11-01)

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.
gan: Kamini Kunasegaran, et al.
Cyhoeddwyd: (2014-01-01)

Discordant genome assemblies drastically alter the interpretation of single-cell RNA sequencing data which can be mitigated by a novel integration method
gan: Potts, HG, et al.
Cyhoeddwyd: (2022)

Atrioventricular Block in Children
gan: Igor A. Kovalev, et al.
Cyhoeddwyd: (2018-12-01)

Reflex Atrioventricular Block
gan: Richard Sutton
Cyhoeddwyd: (2020-04-01)

Bloqueio atrioventricular congênito
gan: José Mário Baggio Junior, et al.
Cyhoeddwyd: (2017-07-01)