Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia
The loss of functional genes from non-recombining sex-specific chromosomes [1, 2], such as the Y chromosomes in mammals [3] or W chromosomes in birds [4], should result in an imbalance of gene products for sex-linked genes [5]. Different chromosome-wide systems that rebalance gene expression are kno...
| Main Authors: | , , , , |
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| Format: | Journal article |
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Cell Press
2019
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| _version_ | 1826300964493066240 |
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| author | Krasovec, M Kazama, Y Ishii, K Abe, T Filatov, D |
| author_facet | Krasovec, M Kazama, Y Ishii, K Abe, T Filatov, D |
| author_sort | Krasovec, M |
| collection | OXFORD |
| description | The loss of functional genes from non-recombining sex-specific chromosomes [1, 2], such as the Y chromosomes in mammals [3] or W chromosomes in birds [4], should result in an imbalance of gene products for sex-linked genes [5]. Different chromosome-wide systems that rebalance gene expression are known to operate in organisms with relatively old sex chromosomes [6]; e.g., Drosophila overexpress X-linked genes in males [7], while mammals shut down one of the X chromosomes in females [8]. It is not known how long it takes for a chromosome-wide dosage compensation system to evolve. To shed light on the early evolution of dosage compensation, we constructed a high-density Y-deletion map and used deletion mutants to manipulate gene dose and analyze gene expression in white campion (Silene latifolia), which evolved dioecy and sex chromosomes only 11 million years ago [9]. We demonstrate that immediate dosage compensation can be triggered by deletions in a large portion of the p arm of the Y chromosome. Our results indicate that dosage compensation in S. latifolia does not have to evolve gene by gene because a system to upregulate gene expression is already operating on part of the X chromosome, which likely represents an intermediate step in the evolution of a chromosome-wide dosage compensation system in this species. |
| first_indexed | 2024-03-07T05:25:10Z |
| format | Journal article |
| id | oxford-uuid:e04c5963-b3d8-4a37-b37e-e5ba01609783 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:25:10Z |
| publishDate | 2019 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:e04c5963-b3d8-4a37-b37e-e5ba016097832022-03-27T09:46:09ZImmediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifoliaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e04c5963-b3d8-4a37-b37e-e5ba01609783Symplectic Elements at OxfordCell Press2019Krasovec, MKazama, YIshii, KAbe, TFilatov, DThe loss of functional genes from non-recombining sex-specific chromosomes [1, 2], such as the Y chromosomes in mammals [3] or W chromosomes in birds [4], should result in an imbalance of gene products for sex-linked genes [5]. Different chromosome-wide systems that rebalance gene expression are known to operate in organisms with relatively old sex chromosomes [6]; e.g., Drosophila overexpress X-linked genes in males [7], while mammals shut down one of the X chromosomes in females [8]. It is not known how long it takes for a chromosome-wide dosage compensation system to evolve. To shed light on the early evolution of dosage compensation, we constructed a high-density Y-deletion map and used deletion mutants to manipulate gene dose and analyze gene expression in white campion (Silene latifolia), which evolved dioecy and sex chromosomes only 11 million years ago [9]. We demonstrate that immediate dosage compensation can be triggered by deletions in a large portion of the p arm of the Y chromosome. Our results indicate that dosage compensation in S. latifolia does not have to evolve gene by gene because a system to upregulate gene expression is already operating on part of the X chromosome, which likely represents an intermediate step in the evolution of a chromosome-wide dosage compensation system in this species. |
| spellingShingle | Krasovec, M Kazama, Y Ishii, K Abe, T Filatov, D Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title | Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title_full | Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title_fullStr | Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title_full_unstemmed | Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title_short | Immediate dosage compensation is triggered by deletion of Y-linked genes in Silene latifolia |
| title_sort | immediate dosage compensation is triggered by deletion of y linked genes in silene latifolia |
| work_keys_str_mv | AT krasovecm immediatedosagecompensationistriggeredbydeletionofylinkedgenesinsilenelatifolia AT kazamay immediatedosagecompensationistriggeredbydeletionofylinkedgenesinsilenelatifolia AT ishiik immediatedosagecompensationistriggeredbydeletionofylinkedgenesinsilenelatifolia AT abet immediatedosagecompensationistriggeredbydeletionofylinkedgenesinsilenelatifolia AT filatovd immediatedosagecompensationistriggeredbydeletionofylinkedgenesinsilenelatifolia |