Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.
Myeloablative conditioning before bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen-induced TEC damage directly contributes to slow thymopoietic recovery after BMT. Keratino...
Main Authors: | Kelly, R, Goren, E, Taylor, P, Mueller, SN, Stefanski, H, Osborn, M, Scott, H, Komarova, E, Gudkov, A, Holländer, G, Blazar, B |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2010
|
Similar Items
-
Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.
by: Kelly, R, et al.
Published: (2008) -
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
by: Rossi, S, et al.
Published: (2007) -
Thymic T-cell development in allogeneic stem cell transplantation.
by: Krenger, W, et al.
Published: (2011) -
TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
by: Hauri-Hohl, M, et al.
Published: (2008) -
TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
by: Hauri-Hohl, M, et al.
Published: (2008)