Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children.
Combination antiretroviral therapy has had a major role in reducing human immunodeficiency virus type 1 (HIV-1) plasma viral loads in HIV-1-infected adults but a variable effect in infants, in whom complete viral suppression appears to be less readily achieved. In adults, after the reduction in plas...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Conference item |
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1999
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| _version_ | 1797099544118296576 |
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| author | Spiegel, H DeFalcon, E Ogg, G Larsson, M Beadle, T Tao, P Mcmichael, A Bhardwaj, N O'Callaghan, C Cox, W Krasinski, K Pollack, H Borkowsky, W Nixon, D |
| author_facet | Spiegel, H DeFalcon, E Ogg, G Larsson, M Beadle, T Tao, P Mcmichael, A Bhardwaj, N O'Callaghan, C Cox, W Krasinski, K Pollack, H Borkowsky, W Nixon, D |
| author_sort | Spiegel, H |
| collection | OXFORD |
| description | Combination antiretroviral therapy has had a major role in reducing human immunodeficiency virus type 1 (HIV-1) plasma viral loads in HIV-1-infected adults but a variable effect in infants, in whom complete viral suppression appears to be less readily achieved. In adults, after the reduction in plasma viremia, there is a decrease in the numbers of circulating cytotoxic T cell (CTL) effectors and precursors in the majority of patients. This longitudinal study assessed the effect of combination drug therapy on the frequency of HIV-1-specific CTL responses in 8 HIV-1-infected children. Following treatment, the frequency of HIV-1-specific CTL responses initially increased, especially in children with incomplete viral suppression but with increasing CD4+ cell counts. In children with complete viral suppression, the frequency of HIV-1-specific CTL responses decreased, suggesting that viral replication is required to maintain CTL responses in the systemic circulation. |
| first_indexed | 2024-03-07T05:25:17Z |
| format | Conference item |
| id | oxford-uuid:e054ad65-3a3a-4f94-9cf9-7bc23f774329 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:25:17Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:e054ad65-3a3a-4f94-9cf9-7bc23f7743292022-03-27T09:46:29ZChanges in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:e054ad65-3a3a-4f94-9cf9-7bc23f774329Symplectic Elements at Oxford1999Spiegel, HDeFalcon, EOgg, GLarsson, MBeadle, TTao, PMcmichael, ABhardwaj, NO'Callaghan, CCox, WKrasinski, KPollack, HBorkowsky, WNixon, DCombination antiretroviral therapy has had a major role in reducing human immunodeficiency virus type 1 (HIV-1) plasma viral loads in HIV-1-infected adults but a variable effect in infants, in whom complete viral suppression appears to be less readily achieved. In adults, after the reduction in plasma viremia, there is a decrease in the numbers of circulating cytotoxic T cell (CTL) effectors and precursors in the majority of patients. This longitudinal study assessed the effect of combination drug therapy on the frequency of HIV-1-specific CTL responses in 8 HIV-1-infected children. Following treatment, the frequency of HIV-1-specific CTL responses initially increased, especially in children with incomplete viral suppression but with increasing CD4+ cell counts. In children with complete viral suppression, the frequency of HIV-1-specific CTL responses decreased, suggesting that viral replication is required to maintain CTL responses in the systemic circulation. |
| spellingShingle | Spiegel, H DeFalcon, E Ogg, G Larsson, M Beadle, T Tao, P Mcmichael, A Bhardwaj, N O'Callaghan, C Cox, W Krasinski, K Pollack, H Borkowsky, W Nixon, D Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title | Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title_full | Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title_fullStr | Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title_full_unstemmed | Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title_short | Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. |
| title_sort | changes in frequency of hiv 1 specific cytotoxic t cell precursors and circulating effectors after combination antiretroviral therapy in children |
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