Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

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Some 15-20% of multiple adenomatous polyposis have no genetic explanation and 20-30% of colorectal cancer (CRC) cases are thought to be due to inherited multifactorial causes. Accumulation of deleterious effects of low-frequency dominant and independently acting variants may be a partial explanation...

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Dades bibliogràfiques
Autors principals:	Lefevre, J, Bonilla, C, Colas, C, Winney, B, Johnstone, E, Tonks, S, Day, T, Hutnik, K, Boumertit, A, Soubrier, F, Midgley, R, Kerr, D, Parc, Y, Bodmer, W
Format:	Journal article
Idioma:	English
Publicat:	Nature Publishing Group 2012

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