Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

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Some 15-20% of multiple adenomatous polyposis have no genetic explanation and 20-30% of colorectal cancer (CRC) cases are thought to be due to inherited multifactorial causes. Accumulation of deleterious effects of low-frequency dominant and independently acting variants may be a partial explanation...

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Bibliografiske detaljer
Main Authors:	Lefevre, J, Bonilla, C, Colas, C, Winney, B, Johnstone, E, Tonks, S, Day, T, Hutnik, K, Boumertit, A, Soubrier, F, Midgley, R, Kerr, D, Parc, Y, Bodmer, W
Format:	Journal article
Sprog:	English
Udgivet:	Nature Publishing Group 2012

Lignende værker

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af: Lefevre, J, et al.
Udgivet: (2012)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
af: Bonilla, C, et al.
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af: Bonilla, C, et al.
Udgivet: (2015)

Familial adenomatous polyposis (FAP) and its gene, APC.
af: Bodmer, W
Udgivet: (1999)

Familial adenomatous polyposis
af: Rozen Paul, et al.
Udgivet: (2009-10-01)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas
af: Sieber, O, et al.
Udgivet: (2002)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
af: Sieber, O, et al.
Udgivet: (2002)

Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis
af: Emiko Takeshita, et al.
Udgivet: (2017-07-01)

Multiple Adenomatous Duodenal Polyposis
af: Zdena Zádorová, et al.
Udgivet: (2013-01-01)

Familial adenomatous polyposis coli
af: K Boeren, et al.
Udgivet: (2011-03-01)

Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
af: Scott Rodney J
Udgivet: (2003-12-01)

Criteria for choosing non-patient control groups in genetically based case-control studies in the United Kingdom. People of the British Isles: the pilot project
af: Evseeva, I, et al.
Udgivet: (2007)

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients
af: Yozo Suzuki, et al.
Udgivet: (2022-04-01)

Familial Adenomatous Polyposis with Synchronous Colorectal, Bilateral Ovarian, and Uterine Malignancies
af: Bipin Thomas Prasad, et al.
Udgivet: (2021-01-01)

Familial adenomatous polyposis and desmoid tumors
af: Ana Elisa Moraes Righetti, et al.
Udgivet: (2011-01-01)

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
af: Cottrell, S, et al.
Udgivet: (1992)

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.
af: Lefevre, J, et al.
Udgivet: (2010)

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
af: Sieber, O, et al.
Udgivet: (2003)

Familial adenomatous colorectal polyposis complicated by colonic obturation: a clinical case
af: V. M. Durleshter, et al.
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Mucinous colorectal adenocarcinoma in a patient with familial adenomatous polyposis and melanosis coli
af: Yinji Zhou, et al.
Udgivet: (2023-12-01)

The in vivo rate of somatic adenomatous polyposis coli mutation.
af: Hornsby, C, et al.
Udgivet: (2008)

Vaccines for cancer interception in familial adenomatous polyposis
af: David E. Johnson, et al.
Udgivet: (2025-01-01)

Familial adenomatous polyposis: a case report
af: Endeshaw Asaye Kindie, et al.
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A Two Generation of Familial Adenomatous Polyposis
af: Lily Chandrawati, et al.
Udgivet: (2020-07-01)

Microbiome insights into pediatric familial adenomatous polyposis
af: Thomas M. Attard, et al.
Udgivet: (2022-11-01)

Adenomatous polyposis coli in cancer and therapeutic implications
af: Olivia Noe, et al.
Udgivet: (2021-06-01)

Adenomatous Polyposis Coli (APC) in cell migration
af: Xingyuan Fang, et al.
Udgivet: (2022-06-01)

Intestinal and extraintestinal manifestations in familial adenomatous polyposis
af: Nagorni Aleksandar, et al.
Udgivet: (2007-01-01)

Large desmoid tumors in familial adenomatous polyposis
af: Vítor Devezas, et al.
Udgivet: (2018-11-01)

Desmoid tumor in patients with familial adenomatous polyposis
af: Raquel Franco Leal, et al.
Udgivet: (2010-12-01)

Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72
af: Johannsson Oskar, et al.
Udgivet: (2008-11-01)

Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences
af: Pål Møller, et al.
Udgivet: (2025-01-01)

Imatinib: a new chemopreventive option in adenomatous polyposis?
af: María Pellisé, et al.
Udgivet: (2020-12-01)

Familial Adenomatous Polyposis: An Uncommon Autosomal Genetic Condition
af: Simran Khan, et al.
Udgivet: (2024-12-01)

Outcomes following duodenectomy in patients with familial adenomatous polyposis
af: Arthur S. Aelvoet, et al.
Udgivet: (2024-05-01)

Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis
af: Kyriakidis F, et al.
Udgivet: (2023-08-01)

Familial Adenomatous Polyposis (FAP) in 9 Hispanic women
af: Ricker Charite, et al.
Udgivet: (2010-05-01)

A case report of Familial Adenomatous Polyposis (FAP)
af: A Gholizadeh Pasha, et al.
Udgivet: (2003-07-01)

Age and manifestation related symptoms in familial adenomatous polyposis
af: Hohenberger Werner, et al.
Udgivet: (2005-03-01)

Mechanisms of Action of Phytoestrogens and Their Role in Familial Adenomatous Polyposis
af: Irene Falsetti, et al.
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