Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.

Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.

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Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine...

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Bibliographic Details
Main Authors: Jaroensuk, J, Stoesser, N, Leimanis, M, Jittamala, P, White, N, Nosten, F, Mcgready, R
Format: Journal article
Language:English
Published: American Society of Tropical Medicine and Hygiene 2014
Description
Summary:Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.

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