Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
Triazole-carboxylic acids related to D-glucose and D-galactose may be prepared by intramolecular [1,3]-dipolar cycloadditions of azides to unsaturated esters, followed by bromine oxidation of the resulting triazoline. Such materials may provide a series of anionic mimics of carbohydrates.
Main Authors: | Krulle, T, delaFuente, C, Pickering, L, Aplin, RT, Tsitsanou, K, Zographos, SE, Oikonomakos, N, Nash, R, Griffiths, R, Fleet, G |
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格式: | Journal article |
语言: | English |
出版: |
1997
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