Integrative modelling coupled with ion mobility mass spectrometry reveals structural features of the clamp loader in complex with single-stranded DNA binding protein.

Integrative modelling coupled with ion mobility mass spectrometry reveals structural features of the clamp loader in complex with single-stranded DNA binding protein.

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DNA polymerase III, a decameric 420-kDa assembly, simultaneously replicates both strands of the chromosome in Escherichia coli. A subassembly of this holoenzyme, the seven-subunit clamp loader complex, is responsible for loading the sliding clamp (β2) onto DNA. Here, we use structural information de...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Politis, A, Park, A, Hall, Z, Ruotolo, B, Robinson, C
التنسيق: Journal article
اللغة:English
منشور في: 2013
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