Effects of weight loss on myocardial energetics and diastolic function in obesity.
A reduced myocardial phosphocreatine/adenosine triphosphate (PCr/ATP) ratio is linked to both diastolic dysfunction and heart failure. Although obesity is well known to cause diastolic dysfunction a link to impaired cardiac energetics has only recently been established. We assessed whether or not lo...
| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2013
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| _version_ | 1826301029028724736 |
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| author | Rider, O Francis, J Tyler, D Byrne, J Clarke, K Neubauer, S |
| author_facet | Rider, O Francis, J Tyler, D Byrne, J Clarke, K Neubauer, S |
| author_sort | Rider, O |
| collection | OXFORD |
| description | A reduced myocardial phosphocreatine/adenosine triphosphate (PCr/ATP) ratio is linked to both diastolic dysfunction and heart failure. Although obesity is well known to cause diastolic dysfunction a link to impaired cardiac energetics has only recently been established. We assessed whether or not long-term weight loss in obesity, which is known to reduce mortality, is accompanied by both improved cardiac energetics and diastolic function. Normal weight (BMI 22 ± 2; n = 18) and obese subjects (BMI 34 ± 4; n = 13) underwent cine-MRI (1.5 Tesla) to determine left ventricular diastolic function using volume-time curve analysis, and (31)P-MR spectroscopy (3 Tesla) to assess cardiac energetics (PCr/ATP ratio). Obese subjects (n = 13) underwent repeat assessment after 1 year of supervised weight loss. Obesity, in the absence of identifiable cardiovascular risk factors, was associated with significantly impaired myocardial high energy phosphate metabolism (PCr/ATP ratio, normal; 2.03 ± 0.27 vs. obese; 1.58 ± 0.47, p = 0.002) and significantly lower peak diastolic filling rate (normal; 4.8 ± 0.8 vs. obese; 3.8 ± 0.7 EDV/s, p = 0.01). Weight loss (on average 9 kg, 55% excess weight) over 1 year resulted in a 24% increase in PCr/ATP ratio (p = 0.01) and an 18% improvement in peak diastolic filling rate (p = 0.01). Myocardial PCr/ATP ratio remained positively correlated with peak diastolic filling rate after weight loss (r = 0.63, p = 0.02). In obesity, weight loss improves impaired cardiac energetics and myocardial relaxation. Improved myocardial energetics appear to play a key role in diastolic functional recovery accompanying weight loss. |
| first_indexed | 2024-03-07T05:26:09Z |
| format | Journal article |
| id | oxford-uuid:e0a1141c-1b5e-4fba-8070-7dbbf9b6ac6c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:26:09Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:e0a1141c-1b5e-4fba-8070-7dbbf9b6ac6c2022-03-27T09:48:37ZEffects of weight loss on myocardial energetics and diastolic function in obesity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e0a1141c-1b5e-4fba-8070-7dbbf9b6ac6cEnglishSymplectic Elements at Oxford2013Rider, OFrancis, JTyler, DByrne, JClarke, KNeubauer, SA reduced myocardial phosphocreatine/adenosine triphosphate (PCr/ATP) ratio is linked to both diastolic dysfunction and heart failure. Although obesity is well known to cause diastolic dysfunction a link to impaired cardiac energetics has only recently been established. We assessed whether or not long-term weight loss in obesity, which is known to reduce mortality, is accompanied by both improved cardiac energetics and diastolic function. Normal weight (BMI 22 ± 2; n = 18) and obese subjects (BMI 34 ± 4; n = 13) underwent cine-MRI (1.5 Tesla) to determine left ventricular diastolic function using volume-time curve analysis, and (31)P-MR spectroscopy (3 Tesla) to assess cardiac energetics (PCr/ATP ratio). Obese subjects (n = 13) underwent repeat assessment after 1 year of supervised weight loss. Obesity, in the absence of identifiable cardiovascular risk factors, was associated with significantly impaired myocardial high energy phosphate metabolism (PCr/ATP ratio, normal; 2.03 ± 0.27 vs. obese; 1.58 ± 0.47, p = 0.002) and significantly lower peak diastolic filling rate (normal; 4.8 ± 0.8 vs. obese; 3.8 ± 0.7 EDV/s, p = 0.01). Weight loss (on average 9 kg, 55% excess weight) over 1 year resulted in a 24% increase in PCr/ATP ratio (p = 0.01) and an 18% improvement in peak diastolic filling rate (p = 0.01). Myocardial PCr/ATP ratio remained positively correlated with peak diastolic filling rate after weight loss (r = 0.63, p = 0.02). In obesity, weight loss improves impaired cardiac energetics and myocardial relaxation. Improved myocardial energetics appear to play a key role in diastolic functional recovery accompanying weight loss. |
| spellingShingle | Rider, O Francis, J Tyler, D Byrne, J Clarke, K Neubauer, S Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title | Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title_full | Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title_fullStr | Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title_full_unstemmed | Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title_short | Effects of weight loss on myocardial energetics and diastolic function in obesity. |
| title_sort | effects of weight loss on myocardial energetics and diastolic function in obesity |
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